Adipose Tissue-Endothelial Cell Interactions in Obesity-Induced Endothelial Dysfunction

被引：17

作者：

Li, Manna ^{[1
]}

Qian, Ming ^{[1
]}

Kyler, Kathy ^{[2
]}

Xu, Jian ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Harold Hamm Diabet Ctr, Norman, OK 73019 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Off Res Adm, Norman, OK 73019 USA

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷

基金：

美国国家卫生研究院;

关键词：

adipose tissue; endothelial dysfuction; obesity; cell interaction; cardiovascular disease; FATTY LIVER-DISEASE; TREATMENTS AVAILABLE DRUGS; INSULIN-RESISTANCE; CARDIOVASCULAR OUTCOMES; ANGIOCRINE SIGNALS; HEART-FAILURE; RISK; ACTIVATION; EXPRESSION; INTERPLAY;

D O I：

10.3389/fcvm.2021.681581

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity has a strong impact on the pathogenesis of cardiovascular disease, which raises enthusiasm to understand how excess adiposity causes vascular injury. Adipose tissue is an essential regulator of cardiovascular system through its endocrine and paracrine bioactive products. Obesity induces endothelial dysfunction, which often precedes and leads to the development of cardiovascular diseases. Connecting adipose tissue-endothelial cell interplay to endothelial dysfunction may help us to better understand obesity-induced cardiovascular disease. This Mini Review discussed (1) the general interactions and obesity-induced endothelial dysfunction, (2) potential targets, and (3) the outstanding questions for future research.

引用

页数：9

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