Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones

被引：75

作者：

Cacic, Milan ^{[1
]}

Molnar, Maja ^{[1
]}

Sarkanj, Bojan ^{[1
]}

Has-Schoen, Elizabeta ^{[2
]}

Rajkovic, Valentina ^{[2
]}

机构：

[1] JJ Strossmayer Univ, Fac Food Technol, Dept Appl Chem & Ecol, Osijek 31000, Croatia

[2] JJ Strossmayer Univ, Dept Biol, Osijek 31000, Croatia

来源：

MOLECULES | 2010年 / 15卷 / 10期

关键词：

coumarin; hydrazides; aromatic Schiff's bases; N-(2-aryl-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide; antioxidant activity; biological activity; BIDENTATE SCHIFF-BASES; COUMARIN DERIVATIVES; BIOLOGICAL-ACTIVITY; MANNICH-BASES; ANTIMICROBIAL ACTIVITY; ANTIBACTERIAL; ANTIFUNGAL; COMPLEXES; ACID; 4-THIAZOLIDINONE;

D O I：

10.3390/molecules15106795

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of Schiff's bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-1 and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy) acetamides 3a-1 were synthesized and evaluated for their antioxidant activity by the phosphomolybdenum method. Most of the Schiff's bases and thiazolidine-4-ones bearing two hydroxyl groups on the phenyl ring showed excellent antioxidant activity in comparison with ascorbic acid. Preliminary investigation on cytotoxic and antifungal activity was done on some representative samples.

引用

页码：6795 / 6809

页数：15

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