Electrostatics of DNA cationic lipid complexes: isoelectric instability

被引:141
作者
Bruinsma, R [1 ]
机构
[1] Univ Calif Los Angeles, Dept Phys, Los Angeles, CA 90024 USA
关键词
D O I
10.1007/s100510050353
中图分类号
O469 [凝聚态物理学];
学科分类号
070205 ;
摘要
We propose a Poisson-Boltzmann electrostatic theory for DNA/cationic lipid complexes modeled as a stack of aligned DNA chains intercalated with lipid bilayers, a structure suggested by the recent X-ray synchrotron studies of Radler et al. Poisson-Boltzmann theory is shown to predict that the isoelectric point - where the DNA and cationic lipid charges are in balance - is unstable against absorption of extra DNA or lipid material. The instability is caused by the entropy gain obtained following the release of small ions inside the complex and is manifested by singular behavior of the rod-rod spacing near the isoelectric point. We apply the theory to a discussion of the results of Radler et al.
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页码:75 / 88
页数:14
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