Biomarkers for Early Diagnosis of Acute Kidney Injury: Current Progress and Clinical Prospects

被引：11
作者：
Huang, Hong-Feng [1 ,2 ,3 ,4 ]
Zhou, Jing-Yi [1 ,2 ,3 ,4 ]
Chen, Jiang-Hua [1 ,2 ,3 ,4 ]
机构：
[1] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Kidney Dis Ctr, Qingchun Rd 79, Hangzhou 310003, Zhejiang, Peoples R China
[2] Key Lab Nephropathy, Hangzhou, Zhejiang, Peoples R China
[3] State Adm Tradit Chinese Med, Grade Lab 3, Kidney Dis Immunol Lab, Hangzhou, Zhejiang, Peoples R China
[4] Minist Hlth China, Key Lab Multiple Organ Transplantat, Hangzhou, Zhejiang, Peoples R China
来源：
CURRENT PROTEIN & PEPTIDE SCIENCE | 2017年 / 18卷 / 12期
关键词：
Acute kidney injury; biomarkers; cystatin C; IL-18; KIM-1; L-FABP; NGAL; NHE-3; GELATINASE-ASSOCIATED LIPOCALIN; EARLY URINARY BIOMARKER; DELAYED GRAFT FUNCTION; ACID-BINDING PROTEIN; ACUTE-RENAL-FAILURE; SERUM CYSTATIN-C; NHE3; PROTEIN; NGAL; MARKER; IL-18;
D O I：
10.2174/1389203717666160909152205
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Acute kidney injury (AKI) is one of the most common complications in critically ill patients, resulting in high morbidity and mortality. AKI usually occurs after major surgery, severe infection or drug-induced nephrotoxicity and is associated with prolonged hospital stays, increased costs and adverse clinical outcomes. The diagnosis of AKI is currently based on decreased glomerular filtration rate (GFR) and urine output, and increased serum creatinine. Novel biomarkers are required for early identification of patients with AKI to allow timely therapy and improve patient outcomes. With the advent of proteomics and genomics techniques, a vast array of biomarkers are now available in clinical practice.
引用
收藏
页码：1205 / 1210
页数：6
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