Bisphenols and Thyroid Hormone

被引：81

作者：

Kim, Min Joo ^{[1
]}

Park, Young Joo ^{[2
]}

机构：

[1] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Internal Med, Seoul, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Internal Med, 101 Daehak Ro, Seoul 03080, South Korea

来源：

ENDOCRINOLOGY AND METABOLISM | 2019年 / 34卷 / 04期

关键词：

Bisphenol A; Endocrine disruptors; Thyroid hormones; Receptors; thyroid hormone; IN-VITRO; URINARY PHTHALATE; A CONCENTRATIONS; SERUM THYROXINE; EXPOSURE; ASSOCIATION; DISRUPTION; EXPRESSION; ALTERS; METABOLITES;

D O I：

10.3803/EnM.2019.34.4.340

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In recent decades, attention has been directed toward the effects of bisphenol A (BPA) on human health. BPA has estrogenic activity and is regarded as a representative endocrine disruptor. In addition, mounting evidence indicates that BPA can disrupt thyroid hormone and its action. This review examined human epidemiological studies to investigate the association between BPA exposure and thyroid hormone levels. and analyzed in vivo and in vitro experiments to identify the causal relationship and its mechanism of action. BPA is involved in thyroid hormone action not only as a thyroid hormone receptor antagonist, but also through several other mechanisms. Since the use of bisphenols other than BPA has recently increased, we also reviewed the effects of other bisphenols on thyroid hormone action.

引用

页码：340 / 348

页数：9

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