A Biomimetic Total Synthesis of (+)-Ainsliadimer A

被引：69

作者：

Li, Chao ^{[1
]}

Yu, Xueliang ^{[1
]}

Lei, Xiaoguang ^{[1
,2
]}

机构：

[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

[2] NIBS, Beijing 102206, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 19期

关键词：

DIELS-ALDER REACTIONS; SESQUITERPENE LACTONES; NATURAL-PRODUCTS; CATALYSIS; KINETICS; KETONES; DIMER;

D O I：

10.1021/ol101705j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protecting group free and biomimetic total synthesis of (+)-ainsliadimer A has been accomplished in 14 steps from a-santonin. The synthesis relies on a hydrogen bonding promoted [4 + 2]-hetero-Diels-Alder dimerization to afford the key homodimer intermediate, which demonstrates the feasibility of using nonenzymatic conditions to achieve the proposed biosynthesis.

引用

页码：4284 / 4287

页数：4

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