Progress and challenges in the therapy of adult acute lymphoblastic leukemia

被引:10
作者
Kebriaei, P
Larson, RA
机构
[1] Univ Chicago, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA
[2] Univ Chicago, Canc Res Ctr, Chicago, IL 60637 USA
关键词
D O I
10.1097/00062752-200307000-00006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acute lymphoblastic leukemia is a heterogeneous disease with distinct biologic and prognostic groupings. Although current therapies result in high complete remission rates, long-term disease-free survival rates have remained disappointingly low. Results from recent studies using risk-tailored approaches suggest improvement in overall survival for high-risk groups, such as those with Philadelphia chromosome-positive acute lymphoblastic leukemia. Furthermore, the incorporation of imatinib mesylate into the treatment regimen for Philadelphia chromosome-positive acute lymphoblastic leukemia patients may lead to better outcomes. Finally, quantification of minimal residual disease at various time points during therapy is being investigated as a means to predict more accurately a patient's response to therapy, and to make therapeutic decisions.
引用
收藏
页码:284 / 289
页数:6
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