Pancreatic neuroendocrine tumors: Challenges in an underestimated disease

被引:16
作者
Viudez, A. [1 ]
De Jesus-Acosta, A. [2 ]
Carvalho, F. L. [3 ]
Vera, R. [1 ]
Martin-Algarra, S. [4 ]
Ramirez, N. [5 ]
机构
[1] Complejo Hosp Navarra, IdiSNA Navarra Inst Hlth Res, Navarra Publ Hlth Syst, Dept Med Oncol, C Irunlarrea 3, Pamplona 31008, Navarra, Spain
[2] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Dept Med Oncol, Baltimore, MD 21205 USA
[3] Georgetown Univ Hosp, Dept Urol, Washington, DC 20007 USA
[4] Univ Navarra, Univ Navarra Clin, IdiSNA Navarra Inst Hlth Res, Dept Med Oncol, Pamplona, Spain
[5] Navarrabiomed Miguel Servet Fdn, IdiSNA Navarra Inst Hlth Res, Navarra Publ Hlth Syst, Oncohematol Res Grp, C Irunlarrea 3, Pamplona 31008, Spain
关键词
Pancreatic Neuroendocrine Tumor (PanNET); Gastrointestinal neuroendocrine tumors; Foregut; Targeted therapies; Pancreas surgery; PLASMA CHROMOGRANIN-A; ENETS CONSENSUS GUIDELINES; ZOLLINGER-ELLISON-SYNDROME; SOMATOSTATIN RECEPTOR SCINTIGRAPHY; NECROLYTIC MIGRATORY ERYTHEMA; ENDOCRINE NEOPLASIA TYPE-1; HIPPEL-LINDAU DISEASE; INSTITUTES-OF-HEALTH; LIVER METASTASES; PHASE-II;
D O I
10.1016/j.critrevonc.2016.03.013
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Pancreatic neuroendocrine tumours (PanNETs) are considered a relatively unusual oncologic entity. Due to its relative good prognosis, surgery remains the goal standard therapy not only in localized disease but also in the setting of locally or metastatic disease. Most of the patients are diagnosed in metastatic scenario, where multidisciplinary approach based on surgery, chemotherapies, liver-directed and/or molecular targeted therapies are commonly used. Owing to a deeper molecular knowledge of this disease, these targeted therapies are nowadays widely implemented, being the likely discovery of predictive biomarkers that would allow its use in other settings. This review is focused on describing the different classifications, etiology, prognostic biomarkers and multidisciplinary approaches that are typically used in PanNET. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:193 / 206
页数:14
相关论文
共 50 条
[41]   Pancreatic neuroendocrine tumors: Clinical features, diagnosis and medical treatment: Advances [J].
Ito, Tetsuhide ;
Igarashi, Hisato ;
Jensen, Robert T. .
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2012, 26 (06) :737-753
[42]   Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review [J].
Haugvik, Sven-Petter ;
Labori, Knut Jorgen ;
Edwin, Bjorn ;
Mathisen, Oystein ;
Gladhaug, Ivar Prydz .
SCIENTIFIC WORLD JOURNAL, 2012,
[43]   Update on pancreatic neuroendocrine tumors [J].
McKenna, Logan R. ;
Edil, Barish H. .
GLAND SURGERY, 2014, 3 (04) :258-275
[44]   RADIOTHERAPY FOR PANCREATIC NEUROENDOCRINE TUMORS [J].
Contessa, Joseph N. ;
Griffith, Kent A. ;
Wolff, Elizabeth ;
Ensminger, William ;
Zalupski, Mark ;
Lawrence, Theodore S. ;
Ben-Josef, Edgar .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 75 (04) :1196-1200
[45]   Pancreatic neuroendocrine tumors: a review [J].
Young, Kate ;
Iyer, Ridhima ;
Morganstein, Daniel ;
Chau, Ian ;
Cunningham, David ;
Starling, Naureen .
FUTURE ONCOLOGY, 2015, 11 (05) :853-864
[46]   Genetics of Pancreatic Neuroendocrine Tumors [J].
Mohindroo, Chirayu ;
McAllister, Florencia ;
De Jesus-Acosta, Ana .
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2022, 36 (05) :1033-1051
[47]   Pancreatic Neuroendocrine Tumors: Signal Pathways and Targeted Therapies [J].
Peng, L. ;
Schwarz, R. E. .
CURRENT MOLECULAR MEDICINE, 2013, 13 (03) :333-339
[48]   Molecular alterations and therapeutic targets in pancreatic neuroendocrine tumors [J].
Ma, Yarui ;
Wang, Xiaoyue ;
Zhao, Hong ;
Jiao, Yuchen .
JOURNAL OF PANCREATOLOGY, 2023, 6 (03) :119-126
[49]   Preoperative imaging and pathologic classification for pancreatic neuroendocrine tumors [J].
Deguelte, S. ;
de Mestier, L. ;
Hentic, O. ;
Cros, J. ;
Lebtahi, R. ;
Hammel, P. ;
Kianmanesh, R. .
JOURNAL OF VISCERAL SURGERY, 2018, 155 (02) :117-125
[50]   Molecular Signatures and Their Clinical Utility in Pancreatic Neuroendocrine Tumors [J].
Chatani, Praveen Dilip ;
Agarwal, Sunita Kishore ;
Sadowski, Samira Mercedes .
FRONTIERS IN ENDOCRINOLOGY, 2021, 11