Pancreatic neuroendocrine tumors: Challenges in an underestimated disease

被引：15

作者：

Viudez, A. ^{[1
]}

De Jesus-Acosta, A. ^{[2
]}

Carvalho, F. L. ^{[3
]}

Vera, R. ^{[1
]}

Martin-Algarra, S. ^{[4
]}

Ramirez, N. ^{[5
]}

机构：

[1] Complejo Hosp Navarra, IdiSNA Navarra Inst Hlth Res, Navarra Publ Hlth Syst, Dept Med Oncol, C Irunlarrea 3, Pamplona 31008, Navarra, Spain

[2] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Dept Med Oncol, Baltimore, MD 21205 USA

[3] Georgetown Univ Hosp, Dept Urol, Washington, DC 20007 USA

[4] Univ Navarra, Univ Navarra Clin, IdiSNA Navarra Inst Hlth Res, Dept Med Oncol, Pamplona, Spain

[5] Navarrabiomed Miguel Servet Fdn, IdiSNA Navarra Inst Hlth Res, Navarra Publ Hlth Syst, Oncohematol Res Grp, C Irunlarrea 3, Pamplona 31008, Spain

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2016年 / 101卷

关键词：

Pancreatic Neuroendocrine Tumor (PanNET); Gastrointestinal neuroendocrine tumors; Foregut; Targeted therapies; Pancreas surgery; PLASMA CHROMOGRANIN-A; ENETS CONSENSUS GUIDELINES; ZOLLINGER-ELLISON-SYNDROME; SOMATOSTATIN RECEPTOR SCINTIGRAPHY; NECROLYTIC MIGRATORY ERYTHEMA; ENDOCRINE NEOPLASIA TYPE-1; HIPPEL-LINDAU DISEASE; INSTITUTES-OF-HEALTH; LIVER METASTASES; PHASE-II;

D O I：

10.1016/j.critrevonc.2016.03.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic neuroendocrine tumours (PanNETs) are considered a relatively unusual oncologic entity. Due to its relative good prognosis, surgery remains the goal standard therapy not only in localized disease but also in the setting of locally or metastatic disease. Most of the patients are diagnosed in metastatic scenario, where multidisciplinary approach based on surgery, chemotherapies, liver-directed and/or molecular targeted therapies are commonly used. Owing to a deeper molecular knowledge of this disease, these targeted therapies are nowadays widely implemented, being the likely discovery of predictive biomarkers that would allow its use in other settings. This review is focused on describing the different classifications, etiology, prognostic biomarkers and multidisciplinary approaches that are typically used in PanNET. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：193 / 206

页数：14