Data on statistical experimental design to formulate amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis

被引：1

作者：

Melo, Carolina M. ^{[1
]}

Cardoso, Jessica F. ^{[2
]}

Perasoli, Fernanda B. ^{[2
]}

Marques, Maria Betania F. ^{[3
]}

Mussel, Wagner N. ^{[3
]}

Moura, Sandra A. L. ^{[4
]}

Da Silva, Gisele R. ^{[2
]}

机构：

[1] Univ Fed Sao Joao del Rei, Sch Pharm, Divnopolis, MG, Brazil

[2] Univ Fed Ouro Preto, Sch Pharm, Ouro Preto, MG, Brazil

[3] Univ Fed Minas Gerais, Chem Dept, Belo Horizonte, MG, Brazil

[4] Univ Fed Ouro Preto, Dept Biol Sci, Ouro Preto, MG, Brazil

来源：

DATA IN BRIEF | 2020年 / 29卷

关键词：

Eudragit RL100; Amphotericin B; Hyaluronic acid; Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid; Vulvovaginal candidiasis;

D O I：

10.1016/j.dib.2020.105311

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Data described in this article are related to the research article entitled "Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid (AMP EUD nanoparticles/HA) for the treatment of vulvovaginal candidiasis" [1]. In this work, we report original data on the statistical experimental design to formulate uncoated AMP EUD nanoparticles, data on the validation of spectrophotometric method to quantify the AMP released from uncoated EUD nanoparticles and coated with HA to obtain the in vitro drug release profiles as well as the drug encapsulation efficiency. In addition, we describe original data on characterization, including diameter size, polydispersity index, zeta potential, FTIR, DSC/TG, and XRD; data on diameter of in vitro inhibition halos of Candida albicans; and on the vaginal burden of infected animals treated with uncoated AMP EUD nanoparticles and AMP EUD nanoparticles/HA. Finally, different histological sections of endocervix collected from treated and untreated animals were inserted into this manuscript. (C) 2020 The Author(s). Published by Elsevier Inc.

引用

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