High expression of GPR116 indicates poor survival outcome and promotes tumor progression in colorectal carcinoma

被引:46
作者
Yang, Li [1 ]
Lin, Xiao-Lu [1 ]
Liang, Wei [3 ]
Fu, Seng-Wang [4 ]
Lin, Wen-Feng [1 ]
Tian, Xiao-Qing [1 ]
Gao, Yun-Jie [1 ]
Chen, Hao-Yan [2 ]
Dai, Jun [1 ]
Ge, Zhi-Zheng [1 ]
机构
[1] Shanghai Jiao Tong Univ, Key Lab Gastroenterol & Hepatol, Div Gastroenterol & Hepatol,Sch Med, Shanghai Inst Digest Dis,Minist Hlth,Renji Hosp, Shanghai 200001, Peoples R China
[2] Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes,Renji Hos, Key Lab Gastroenterol & Hepatol,Minist Hlth,Sch M, Div Gastroenterol & Hepatol,Shanghai Inst Digest, Shanghai 200001, Peoples R China
[3] Fujian Med Univ, Fujian Prov Hosp, Prov Clin Med Coll, Dept Digest Endoscopy, Fuzhou 350001, Peoples R China
[4] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Gastroenterol, Sch Med, Shanghai 200080, Peoples R China
基金
中国国家自然科学基金;
关键词
GPR116; prognosis; metastasis; colorectal carcinoma; PROTEIN-COUPLED RECEPTORS; EPITHELIAL-MESENCHYMAL TRANSITION; SIGNALING PATHWAY; CANCER METASTASIS; ADHESION-GPCRS; RECTAL-CANCER; INVASION; CELLS; EMT;
D O I
10.18632/oncotarget.18204
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Previous studies have found that G-protein-coupled receptor 116 (GPR116) is a regulator of breast cancer metastasis. However, the role of GPR116 in colorectal carcinoma (CRC) carcinogenesis and progression is unknown. In this study, We found GPR116 expression was significantly up-regulated in CRC specimens compared with corresponding non-cancerous tissues. Increased GPR116 expression in CRC was correlated with histological differentiation and distant metastasis. In addition, high expression of GPR116 was significantly associated with poor overall survival of CRC patients, which was also confirmed by GSE14333, GSE17536 and GSE33113 datasets from the Gene Expression Omnibus (GEO). Furthermore, we demonstrated that the ability of proliferation and invasion of CRC cell lines HCT116 and LOVO was markedly reduced after transfected with siRNA-GPR116. Meanwhile, GPR116 may drive EMT in CRC cells through AKT/EKR signaling pathway, resulting in metastasis. Thus, GPR116 may be a novel reliable prognostic indicator and a risk factor in CRC progression.
引用
收藏
页码:47943 / 47956
页数:14
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