Study on UHMWPE Carrying Estradiol to Treat the Particle-Induced Osteolysis

被引：0

作者：

Qu, Shuxin ^{[1
]}

Liu, Aiqin ^{[1
]}

Liu, Xiaomin ^{[1
]}

Li, Shengfu ^{[2
]}

Weng, Jie ^{[1
]}

Zhou, Zhongrong ^{[1
]}

机构：

[1] Southwest Jiaotong Univ, Minist Educ, Key Lab Adv Technol Mat, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Lab Transplant Engn & Immunol, Chengdu 610041, Sichuan, Peoples R China

来源：

ADVANCED TRIBOLOGY | 2009年

基金：

中国国家自然科学基金;

关键词：

UHMWPE; 17 beta-estradiol (E2); Osteolysis; Wear; BONE-RESORPTION; RAT MODEL; POLYETHYLENE; WEAR;

D O I：

10.1007/978-3-642-03653-8_282

中图分类号：

TH [机械、仪表工业];

学科分类号：

0802 ;

摘要：

The wear particle-induced osteolysis problem was considered as the major concern for limiting the life of total joint prostheses. In the present study, 17 beta-estradiol (E2), which is one of the estrogens with the potential application on osteolysis treatment, was added into UHMWPE to prepare UHMWPE-E2. The mechanical properties and wear performance of UHMWPE-E2 were characterized. Cell culture experiment was used to evaluate the effect of UHMWPE-E2 wear debris on osteoblasts. The results showed that the UHMWPE-E2 possessed the approving mechanical properties and wear performance compared to the control UHMWPE. And the cell culture results suggested that the expression of Interleukin-6 (IL-6) could be inhibited when the osteoblasts were co-cultured with UHMWPE-E2 wear debris, which indicated the UHMWPE-E2 may be the potential candidate for the implanted drug carrier to prevent the particle-induced osteolysis in joint replacements.

引用

页码：845 / +

页数：2

共 6 条

[1] Topical, single dose bisphosphonate treatment reduced bone resorption in a rat model for prosthetic loosening [J].