Proton Beam Therapy for Loco-Regional Control of a Recurrent Mixed Malignant Germ Cell Tumor of the Skull in a 22-Month-Old Girl

被引：1
作者：
Calaminus, G. [1 ]
Goebel, U. [2 ]
Schrum, J. [3 ]
Wittkugel, O. [4 ]
Westphal, M. [5 ]
Timmermann, B. [6 ]
机构：
[1] Univ Munster, D-48129 Munster, Germany
[2] Univ Dusseldorf, Coordinat Ctr Clin Studies, ESPED Surveillance Unit, Dusseldorf, Germany
[3] Univ Hosp Hamburg Eppendorf, Dept Pediat Hematol & Oncol, Hamburg, Germany
[4] Univ Hosp Hamburg Eppendorf, Dept Neurol Diagnost & Intervent, Hamburg, Germany
[5] Univ Hosp Hamburg Eppendorf, Dept Neurosurg, Hamburg, Germany
[6] W German Protontherapy Ctr Univ Essen, Essen, Germany
来源：
KLINISCHE PADIATRIE | 2010年 / 222卷 / 03期
关键词：
head and neck; infants; germ cell tumors; local tumor control; proton beam therapy; COMBINATION CHEMOTHERAPY; CHILDREN; CANCER; TERATOMAS; ADOLESCENTS; CHILDHOOD; CISPLATIN; ETOPOSIDE; INTERGROUP; BLEOMYCIN;
D O I：
10.1055/s-0030-1252018
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Background: Germ cell tumors (GCT) situated in the head and neck region are very rare and occur predominantely in newborns or young infants. Recurrent CTs are often resectable only by mutilating surgery and the need for alternative treatment strategies is obvious. In this situation radiation therapy is the most important treatment option for loco-regional tumor control, but bear in this area the risk of possible impairment of brain function and face deformation as long term effects. Case report: In a girl with a connatal expansive growing teratoma of the skull the tumor recurred in spite of repeated surgery as mixed malignant GCT at the age of 15 months. Tumor control could not be achieved with chemotherapy and additional surgery seemed not promising. Therefore high dose proton beam therapy (PT) (54 Gy) has been administered to the child at the age of 22 months and led to local tumor control with only mild side effects. Conclusion: PT treatment may be an option for specific clinical conditions in germ cell tumors where local tumor control cannot be achieved by chemotherapy and/or surgery and long lasting side effects of conventional radiotherapy due to tumor localization and age have to be considered. However, PT should be implemented in treatment protocols for specific situations to guarantee supervised application, central documentation and follow-up.
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页码：175 / 179
页数：5
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