Substituent-controlled chemoselective synthesis of multi-substituted pyridones via a one-pot three-component cascade reaction

被引：26
|
作者：
Liu, Shitao [1 ]
Li, Jisen [1 ]
Lin, Junjie [1 ]
Liu, Fujun [1 ]
Liu, Teng [2 ]
Huang, Chao [1 ]
机构：
[1] Yunnan Minzu Univ, Key Lab Intelligent Supramol Chem Univ Yunnan Pro, Sch Chem & Environm, Natl & Local Joint Engn Res Ctr Green Preparat Te, Kunming 650500, Yunnan, Peoples R China
[2] Qujing Normal Univ, Ctr Yunnan Guizhou Plateau Chem Funct Mat & Pollu, Qujing 655011, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 06期
基金：
中国国家自然科学基金;
关键词：
QUINONE IMINE KETALS; SOLVENT-FREE; 2-PYRIDONE SYNTHESIS; EFFICIENT SYNTHESIS; HIGHLY EFFICIENT; FACILE SYNTHESIS; DOMINO; CONSTRUCTION; DERIVATIVES; ENAMINONES;
D O I：
10.1039/c9ob02456e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and concise one-pot strategy for the synthesis of multisubstituted pyridones via a one-pot three-component cascade reaction catalyzed by Cs2CO3 under solvent-free conditions has been developed. The substituent-controlled chemoselective cycloaddition process involved steps including a Michael addition/ethanol elimination/intermolecular cyclization sequence utilizing anilines, diethyl acetylenedicarboxylate, and diethyl ethoxymethylenemalonate. In doing so, various 2-pyridone and 4-pyridone species (41 examples) could be obtained in good to excellent yields.
引用
收藏
页码：1130 / 1134
页数：5
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