Bioactive sesquiterpenoids from the flowers of Inula japonica

被引：29
作者：
Wu, Xing-De [1 ]
Ding, Lin-Fen [2 ,3 ]
Tu, Wen-Chao [1 ,2 ,3 ]
Yang, Hui [1 ,2 ,3 ]
Su, Jia [1 ]
Peng, Li-Yan [1 ]
Li, Yan [1 ]
Zhao, Qin-Shi [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
[3] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
来源：
PHYTOCHEMISTRY | 2016年 / 129卷
基金：
中国国家自然科学基金;
关键词：
Inula japonica; Asteraceae; Sesquiterpenoids; Inujaponins A-I; Cytotoxicity; Nitric oxide (NO); NITRIC-OXIDE PRODUCTION; LACTONES; BRITANNICA; CONSTITUENTS; THUNB;
D O I：
10.1016/j.phytochem.2016.07.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phytochemical investigation of the flowers of Inula japonica led to isolation of nine sesquiterpenoids, inujaponins A-I, as well as eighteen known ones. These sesquiterpenoids belong to six skeletal-types, including eudesmane, 1,10-seco-eudesmane, germacrane, guaiane, 4,5-seco-guaiane, and pseudoguaiane sesquiterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of inujaponin A, eupatolide, and deacetylovatifolin were determined by Cu-K alpha Xray crystallographic analysis. Most of the isolated compounds exhibited potent cytotoxicity against HL 60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines, with IC50 values ranging from 1.57 to 22.58 mu M. Some selected compounds also possessed significant inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values ranging from 1.42 to 8.99 mu M. (C) 2016 Elsevier Ltd. All rights reserved.
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收藏
页码：68 / 76
页数：9
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