Bioactive sesquiterpenoids from the flowers of Inula japonica

被引：29

作者：

Wu, Xing-De ^{[1
]}

Ding, Lin-Fen ^{[2
,3
]}

Tu, Wen-Chao ^{[1
,2
,3
]}

Yang, Hui ^{[1
,2
,3
]}

Su, Jia ^{[1
]}

Peng, Li-Yan ^{[1
]}

Li, Yan ^{[1
]}

Zhao, Qin-Shi ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China

[3] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China

来源：

PHYTOCHEMISTRY | 2016年 / 129卷

基金：

中国国家自然科学基金;

关键词：

Inula japonica; Asteraceae; Sesquiterpenoids; Inujaponins A-I; Cytotoxicity; Nitric oxide (NO); NITRIC-OXIDE PRODUCTION; LACTONES; BRITANNICA; CONSTITUENTS; THUNB;

D O I：

10.1016/j.phytochem.2016.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of the flowers of Inula japonica led to isolation of nine sesquiterpenoids, inujaponins A-I, as well as eighteen known ones. These sesquiterpenoids belong to six skeletal-types, including eudesmane, 1,10-seco-eudesmane, germacrane, guaiane, 4,5-seco-guaiane, and pseudoguaiane sesquiterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of inujaponin A, eupatolide, and deacetylovatifolin were determined by Cu-K alpha Xray crystallographic analysis. Most of the isolated compounds exhibited potent cytotoxicity against HL 60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines, with IC50 values ranging from 1.57 to 22.58 mu M. Some selected compounds also possessed significant inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values ranging from 1.42 to 8.99 mu M. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：68 / 76

页数：9

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