Calcitonin gene-related peptide enhances apoptosis of thymocytes

被引：1
作者：
Sakuta, H [1 ]
Inaba, K [1 ]
Muramatsu, S [1 ]
机构：
[1] KYOTO UNIV, FAC SCI, DEPT ZOOL, SAKYO KU, KYOTO 60601, JAPAN
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1996年 / 67卷 / 02期
关键词：
mouse; calcitonin gene-related peptide; apoptosis; thymocyte; cAMP;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The effect of calcitonin gene-related peptide (CGRP), a neuropeptide, on the apoptosis of murine thymocytes was investigated. CGRP enhanced apoptosis of thymocytes beyond the spontaneous level at concentrations of 10(-11) M or higher, and the effect attained a plateau at 10(-9) M, mainly by stimulating cAMP formation. Implication of cAMP-independent mechanism was also suggested in the CGRP-induced apoptosis. Flow cytometric analysis revealed that CGRP caused apoptosis preferentially in CD4(+)8(+) thymocytes. In addition, RNA and protein synthesis was required for apoptosis induced by CGRP.
引用
收藏
页码：103 / 109
页数：7
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