Calcitonin gene-related peptide enhances apoptosis of thymocytes

被引：1

作者：

Sakuta, H ^{[1
]}

Inaba, K ^{[1
]}

Muramatsu, S ^{[1
]}

机构：

[1] KYOTO UNIV, FAC SCI, DEPT ZOOL, SAKYO KU, KYOTO 60601, JAPAN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1996年 / 67卷 / 02期

关键词：

mouse; calcitonin gene-related peptide; apoptosis; thymocyte; cAMP;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of calcitonin gene-related peptide (CGRP), a neuropeptide, on the apoptosis of murine thymocytes was investigated. CGRP enhanced apoptosis of thymocytes beyond the spontaneous level at concentrations of 10(-11) M or higher, and the effect attained a plateau at 10(-9) M, mainly by stimulating cAMP formation. Implication of cAMP-independent mechanism was also suggested in the CGRP-induced apoptosis. Flow cytometric analysis revealed that CGRP caused apoptosis preferentially in CD4(+)8(+) thymocytes. In addition, RNA and protein synthesis was required for apoptosis induced by CGRP.

引用

页码：103 / 109

页数：7

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