Protective Role of Heat Shock Proteins in Parkinson's Disease

被引：64

作者：

Aridon, Paolo ^{[1
]}

Geraci, Fabiana

Turturici, Giuseppina

D'Amelio, Marco ^{[1
]}

Savettieri, Giovanni ^{[1
]}

Sconzo, Gabriella

机构：

[1] Univ Palermo, Dipartimento Biol Cellulare & Sviluppo, Palermo, Italy

来源：

NEURODEGENERATIVE DISEASES | 2011年 / 8卷 / 04期

关键词：

Heat shock protein; HSP70; HSP90; Parkinson disease; Parkinson's disease-associated genes; ALPHA-SYNUCLEIN AGGREGATION; HSP90 MOLECULAR CHAPERONE; OXIDATIVE STRESS; CRYSTAL-STRUCTURE; QUALITY-CONTROL; CONFORMATIONAL PROPERTIES; PROTEASOMAL DEGRADATION; MITOCHONDRIAL HSP70; SUBSTANTIA-NIGRA; FIBRIL FORMATION;

D O I：

10.1159/000321548

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Despite a large amount of research, the pathogenetic mechanism of these diseases has not yet been clarified. Abnormal protein folding, oxidative stress, mitochondrial dysfunction, and apoptotic mechanisms have all been reported as causes of neurodegenerative diseases in association with neuroinflammatory mechanisms which, by generating deleterious molecules, could promote the cascade of events leading to neurodegeneration. Heat shock proteins (HSPs) play a central role in preventing protein misfolding and inhibiting apoptotic activity, and represent a class of proteins potentially involved in PD pathogenesis. The present review will focus on two HSPs, HSP70 and HSP90, with the aim of specifying their role in PD pathogenesis. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：155 / 168

页数：14

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