Sequential N-acylamide methylenation-enamide ring-closing metathesis:: a synthetic entry to 1,4-dihydroquinolines

被引：39

作者：

Bennasar, ML ^{[1
]}

Roca, T ^{[1
]}

Monerris, M ^{[1
]}

García-Díaz, D ^{[1
]}

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 23期

关键词：

dimethyltitanocene; olefination; enamides; ring-closing metathesis; 1,4-dihydroquinolines;

D O I：

10.1016/j.tetlet.2005.04.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthetic entry to the 1,4-dihydroquinoline nucleus is reported. The procedure involves the dimethyltitanocene methylenation of N-(alkoxycarbonyl)amides derived from 2-allylanilines, followed by ring-closing metathesis of the resulting enamides. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4035 / 4038

页数：4

共 3 条

[1] Sequential Aza-Claisen Rearrangement and Ring-Closing Metathesis as a Route to 1-Benzazepine Derivatives
Ghosh, Debalina
Thander, Latibuddin
Ghosh, Sanjay K.
Chattopadhyay, Shital K.
SYNLETT, 2008, (19) : 3011 - 3015
[2] Synthesis of unsaturated 1,4-heteroatom-containing benzo-fused heterocycles using a sequential isomerization-ring-closing metathesis strategy
Morgans, Garreth L.
Ngidi, E. Lindani
Madeley, Lee G.
Khanye, Setshaba D.
Michael, Joseph P.
de Koning, Charles B.
van Otterlo, Willem A. L.
TETRAHEDRON, 2009, 65 (51) : 10650 - 10659
[3] Synthesis of N,N′-disubstituted (1R,2R)-1,2-diaminocyclohex-4-enes by a ruthenium-catalyzed ring-closing metathesis reaction
Alvaro, G
Grilli, S
Martelli, G
Savoia, D
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 1999, 1999 (07) : 1523 - 1526

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