Caspase inhibition in liver transplantation: from basic research to clinical studies

被引：13

作者：

Cursio, Raffaele ^{[1
,2
]}

机构：

[1] Hop Archet 2, Serv Chirurg Digest & Transplantat Hepat, Lab Rech Chirurg, F-06202 Nice 2, France

[2] Univ Nice Sophia Antipolis, INSERM, U895, Equipe C3M 2,IFR 50, Nice, France

来源：

HPB | 2010年 / 12卷 / 01期

关键词：

ISCHEMIC-INJURY; IDN-6556; APOPTOSIS; TRIAL; WARM;

D O I：

10.1111/j.1477-2574.2009.00123.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

[No abstract available]

引用

页码：1 / 3

页数：3

共 18 条

[1] Clinical trial of the pan-caspase inhibitor, IDN-6556, in human liver preservation injury [J].

Baskin-Bey, E. S. ;

Washburn, K. ;

Feng, S. ;

Oltersdorf, T. ;

Shapiro, D. ;

Huyghe, MiRa ;

Burgart, L. ;

Garrity-Park, M. ;

van Vilsteren, F. G. I. ;

Oliver, L. K. ;

Rosen, C. B. ;

Gores, G. J. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 (01) :218-225

[2] Liver apoptosis following normothermic ischemia-reperfusion: In vivo evaluation of caspase activity by FLIVO assay in rats [J].

Cursio, R. ;

Colosetti, P. ;

Auberger, P. ;

Gugenheim, J. .

TRANSPLANTATION PROCEEDINGS, 2008, 40 (06) :2038-2041

[3] A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis [J].

Cursio, R ;

Gugenheim, J ;

Ricci, JE ;

Crenesse, D ;

Rostagno, P ;

Maulon, L ;

Saint-Paul, MC ;

Ferrua, B ;

Auberger, P .

FASEB JOURNAL, 1999, 13 (02) :253-261

[4] Gene expression profiling of human liver transplants identifies an early transcriptional signature associated with initial poor graft function [J].

Defamie, V. ;

Cursio, R. ;

Le Brigand, K. ;

Moreilhon, C. ;

Saint-Paul, M. -C. ;

Laurens, M. ;

Crenesse, D. ;

Cardinaud, B. ;

Auberger, P. ;

Gugenheim, J. ;

Barbry, P. ;

Mari, B. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (06) :1221-1236

[5]

Farmer D., 2000, TRANSPLANT REV-ORLAN, V14, P106, DOI DOI 10.1053/TR.2000.4651

[6] Necroptosis: A Specialized Pathway of Programmed Necrosis [J].

Galluzzi, Lorenzo ;

Kroemer, Guido .

CELL, 2008, 135 (07) :1161-1163

[7] A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia [J].

Hoglen, Niel C. ;

Anselmo, Dean M. ;

Katori, Masamichi ;

Kaldas, Marian ;

Shen, Xiu-Da ;

Valentino, Karen L. ;

Lassman, Charles ;

Busuttil, Ronald W. ;

Kupiec-Weglinski, Jerzy W. ;

Farmer, Douglas G. .

LIVER TRANSPLANTATION, 2007, 13 (03) :361-366

[8] ISCHEMIC-INJURY IN LIVER-TRANSPLANTATION - DIFFERENCE IN INJURY SITES BETWEEN WARM AND COLD ISCHEMIA IN RATS [J].

IKEDA, T ;

YANAGA, K ;

KISHIKAWA, K ;

KAKIZOE, S ;

SHIMADA, M ;

SUGIMACHI, K .

HEPATOLOGY, 1992, 16 (02) :454-461

[9] Apoptosis and necrosis in the liver: A tale of two deaths? [J].

Malhi, H ;

Gores, GJ ;

Lemasters, JJ .

HEPATOLOGY, 2006, 43 (02) :S31-S44

[10] z-VAD-fmk-induced non-apoptotic cell death of macrophages: Possibilities and limitations for atherosclerotic plaque stabilization [J].

Martinet, Wim ;

Schrijvers, Dorien M. ;

Herman, Arnold G. ;

De Meyer, Guido R. Y. .

AUTOPHAGY, 2006, 2 (04) :312-314

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