Caspase inhibition in liver transplantation: from basic research to clinical studies

被引:14
作者
Cursio, Raffaele [1 ,2 ]
机构
[1] Hop Archet 2, Serv Chirurg Digest & Transplantat Hepat, Lab Rech Chirurg, F-06202 Nice 2, France
[2] Univ Nice Sophia Antipolis, INSERM, U895, Equipe C3M 2,IFR 50, Nice, France
关键词
ISCHEMIC-INJURY; IDN-6556; APOPTOSIS; TRIAL; WARM;
D O I
10.1111/j.1477-2574.2009.00123.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
[No abstract available]
引用
收藏
页码:1 / 3
页数:3
相关论文
共 18 条
  • [1] Clinical trial of the pan-caspase inhibitor, IDN-6556, in human liver preservation injury
    Baskin-Bey, E. S.
    Washburn, K.
    Feng, S.
    Oltersdorf, T.
    Shapiro, D.
    Huyghe, MiRa
    Burgart, L.
    Garrity-Park, M.
    van Vilsteren, F. G. I.
    Oliver, L. K.
    Rosen, C. B.
    Gores, G. J.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 (01) : 218 - 225
  • [2] Liver apoptosis following normothermic ischemia-reperfusion: In vivo evaluation of caspase activity by FLIVO assay in rats
    Cursio, R.
    Colosetti, P.
    Auberger, P.
    Gugenheim, J.
    [J]. TRANSPLANTATION PROCEEDINGS, 2008, 40 (06) : 2038 - 2041
  • [3] A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis
    Cursio, R
    Gugenheim, J
    Ricci, JE
    Crenesse, D
    Rostagno, P
    Maulon, L
    Saint-Paul, MC
    Ferrua, B
    Auberger, P
    [J]. FASEB JOURNAL, 1999, 13 (02) : 253 - 261
  • [4] Gene expression profiling of human liver transplants identifies an early transcriptional signature associated with initial poor graft function
    Defamie, V.
    Cursio, R.
    Le Brigand, K.
    Moreilhon, C.
    Saint-Paul, M. -C.
    Laurens, M.
    Crenesse, D.
    Cardinaud, B.
    Auberger, P.
    Gugenheim, J.
    Barbry, P.
    Mari, B.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (06) : 1221 - 1236
  • [5] Farmer D., 2000, TRANSPLANT REV-ORLAN, V14, P106, DOI DOI 10.1053/TR.2000.4651
  • [6] Necroptosis: A Specialized Pathway of Programmed Necrosis
    Galluzzi, Lorenzo
    Kroemer, Guido
    [J]. CELL, 2008, 135 (07) : 1161 - 1163
  • [7] A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia
    Hoglen, Niel C.
    Anselmo, Dean M.
    Katori, Masamichi
    Kaldas, Marian
    Shen, Xiu-Da
    Valentino, Karen L.
    Lassman, Charles
    Busuttil, Ronald W.
    Kupiec-Weglinski, Jerzy W.
    Farmer, Douglas G.
    [J]. LIVER TRANSPLANTATION, 2007, 13 (03) : 361 - 366
  • [8] ISCHEMIC-INJURY IN LIVER-TRANSPLANTATION - DIFFERENCE IN INJURY SITES BETWEEN WARM AND COLD ISCHEMIA IN RATS
    IKEDA, T
    YANAGA, K
    KISHIKAWA, K
    KAKIZOE, S
    SHIMADA, M
    SUGIMACHI, K
    [J]. HEPATOLOGY, 1992, 16 (02) : 454 - 461
  • [9] Apoptosis and necrosis in the liver: A tale of two deaths?
    Malhi, H
    Gores, GJ
    Lemasters, JJ
    [J]. HEPATOLOGY, 2006, 43 (02) : S31 - S44
  • [10] z-VAD-fmk-induced non-apoptotic cell death of macrophages: Possibilities and limitations for atherosclerotic plaque stabilization
    Martinet, Wim
    Schrijvers, Dorien M.
    Herman, Arnold G.
    De Meyer, Guido R. Y.
    [J]. AUTOPHAGY, 2006, 2 (04) : 312 - 314