Plasticity of antiepileptic drug targets

Resistance to currently available antiepileptic drugs (AEDs) is a major problem in the treatment of temporal lobe epilepsy that affects approximately 30% of patients. Available evidence suggests that plasticity of AED targets, with a concomitantly decreased sensitivity to AEDs, coexists with other cellular mechanisms to cause drug refractoriness. For an expanded treatment of this topic see Jasper's basic mechanisms of the epilepsies. 4th ed. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.