Effects of statins on the chemoresistance-The antagonistic drug-drug interactions versus the anti-cancer effects

被引：33

作者：

Ahmadi, Yasin ^{[1
]}

Karimian, Ramin ^{[1
]}

Panahi, Yunes ^{[1
]}

机构：

[1] Baqiyatallah Univ Med Sci, Syst Biol & Poisonings Inst, Chem Injuries Res Ctr, Tehran, Iran

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 108卷

关键词：

Cancer; Chemoresistance; Chemotherapy; Prenylation; Statin; COA REDUCTASE INHIBITORS; PRIMARY CULTURED RAT; PREGNANE-X-RECEPTOR; PROSTATE-CANCER RISK; REPORTER GENE ASSAY; CELL-CYCLE ARREST; FACTOR-KAPPA-B; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; PPAR-GAMMA;

D O I：

10.1016/j.biopha.2018.09.122

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

There has been growing interest in the potential anti-cancer activity of statins based on evidence of their anti-proliferative, pro-apoptotic, and radiosensitizing properties, but no studies have focused on the effects of statins on the chemoresistance. In spite of their direct cytostatic/cytotoxic effects on the cancer cells, statins via drug interactions may affect therapeutic effects of the chemotherapy agents and so cause chemoresistance in cancer cells. Here, we aim to present the molecular mechanisms underlying cytotoxic effects of statins on the cancer cells against those mechanisms by which statins may lead to chemoresistance, in order to clarify whether the positive effects of the co-treatment of statins on the efficiency of chemotherapeutic agents is due to the natural anti-cancer effects of statins or it is due to increasing the cellular concentrations of chemotherapy drugs in cancer cells.

引用

页码：1856 / 1865

页数：10

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