Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK293 cells

被引：8

作者：

Song, Tao ^{[1
]}

Zhang, Yuanyuan ^{[1
,2
]}

Song, Qiongtao ^{[1
]}

Han, Xue ^{[1
]}

Guan, Shengjiang ^{[1
]}

Zhang, Xuan ^{[1
,2
]}

Chu, Xi ^{[3
]}

Zhang, Fenghua ^{[1
]}

Zhang, Jianping ^{[1
,2
]}

Chu, Li ^{[1
,2
]}

机构：

[1] Hebei Univ Chinese Med, 3 Xingyuan Rd, Shijiazhuang 050200, Hebei, Peoples R China

[2] Hebei Key Lab Integrat Med Liver Kidney Patterns, Shijiazhuang 050200, Hebei, Peoples R China

[3] Hebei Med Univ, Hosp 4, Dept Pharm, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 2017年 / 31卷 / 06期

关键词：

Bufalin; cardiac arrhythmia; hERG K+ channels; LONG QT SYNDROME; IN-VITRO; PROTEIN TRAFFICKING; POTASSIUM CHANNELS; CALCIUM-CHANNEL; HEK-293; CELLS; BUFADIENOLIDES; BLOCK; DRUG; MICE;

D O I：

10.1111/fcp.12306

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, we investigated the effect of bufalin on the human ether-a-go-go-related gene (hERG) K+ channels using the perforated patch recording technique. We measured a half-maximal inhibitory concentration (IC50) of 24.83 M and maximal inhibitory effect of 39.45 +/- 1.14% with bufalin. These findings suggest that bufalin is a potent hERG K+ channel blocker and may provide a new way for understanding Chan Su-induced arrhythmia.

引用

页码：695 / 700

页数：6

共 24 条

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