Plasma Exosomes Loaded pH-Responsive Carboxymethylcellulose Hydrogel Promotes Wound Repair by Activating the Vascular Endothelial Growth Factor Signaling Pathway in Type 1 Diabetic Mice

被引：13
|
作者：
Huang, Lijuan [1 ]
Shi, Yijie [1 ]
Li, Mengdie [1 ]
Wang, Tao [1 ]
Zhao, Liang [1 ]
机构：
[1] Jinzhou Med Univ, Sch Pharm, Jinzhou 121000, Peoples R China
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2021年 / 17卷 / 10期
关键词：
Plasma; Exosomes; CarboxymethylcelluloseHydrogel; DiabeticWound Healing; VEGF; Copyright; American Scentific Publishers; ANGIOGENESIS; ACID; INFLAMMATION; VEGF; YAP;
D O I：
10.1166/jbn.2021.3165
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Chronic wound healing plagues thousands of diabetic patients and brings social and economic burdens. Plasma exosomes (P-Exos), regarded as nanosized therapeutic agents, have shown therapeutic efficacy in promoting diabetic wound healing. The present work prepared the P-Exos-loaded pH-responsive carboxymethylcellulose (P-Exos-loaded CMC) hydrogel to investigate its ability to accelerate diabetic wound healing and to explore its underlying mechanisms. The results showed that the P-Exos-loaded CMC hydrogel was an effective therapeutic agent for accelerating diabetic wound repair. It promoted the local wound healing process in diabetic type 1 mice and enhanced angiogenesis and re-epithelialization via activating angiogenesis-related pathways mediated by vascular endothelial growth factor (VEGF).
引用
收藏
页码：2021 / 2033
页数：13
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