An African swine fever virus Bcl-2 homolog, 5-HL, suppresses apoptotic cell death

被引：86

作者：

Afonso, CL ^{[1
]}

Neilan, JG ^{[1
]}

Kutish, GF ^{[1
]}

Rock, DL ^{[1
]}

机构：

[1] PLUM ISL ANIM DIS CTR, USDA ARS, GREENPORT, NY 11944 USA

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 07期

关键词：

D O I：

10.1128/JVI.70.7.4858-4863.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here, we show that the African swine fever virus 5-HL gene is a highly conserved, viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with dimerization, mediating cell death, and protein-binding functions, and that its protein product, p21, suppresses apoptotic cell death in the mammalian lymphoid cell line FL5.12. Thus, 5-HL is a true functional viral member of the Bcl-2 gene family.

引用

页码：4858 / 4863

页数：6

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