Development of novel montmorillonite-based sustained release system for oral bromopride delivery.

被引：16

作者：

Bello, Murilo L. ^{[1
]}

Junior, Aridio M. ^{[2
,3
]}

Freitas, Caroline A. ^{[1
]}

Moreira, Marina L. A. ^{[2
]}

Costa, Juliana P. da ^{[1
]}

de Souza, Matheus A. ^{[1
]}

Santos, Bianca A. M. C. ^{[1
]}

de Sousa, Valeria P. ^{[4
]}

Castro, Helena C. ^{[5
]}

Rodrigues, Carlos R. ^{[6
]}

Cabral, Lucio M. ^{[2
,7
]}

机构：

[1] Univ Fed Rio de Janeiro, Fac Farm, Lab Planejamento Farmaceut & Simulacao Computac La, Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Fac Farm, Lab Tecnol Ind Farmaceut LabTIF, Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, Inst Ciencias Farmaceut, Macae, Brazil

[4] Univ Fed Rio de Janeiro, Fac Farm, Lab Controle Qualidade LabCQ, Rio De Janeiro, Brazil

[5] Univ Fed Fluminense, Lab Antibiot Bioquim Ensino & Modelagem Mol LABiEM, Inst Biol, Niteroi, Brazil

[6] Univ Fed Rio de Janeiro, Fac Farm, Lab ModMolQSAR, Rio De Janeiro, Brazil

[7] Univ Fed Rio de Janeiro, Fac Farm, Lucio Mendes Cabral, Lab Tecnol Ind Farmaceut, BR-21941590 Rio De Janeiro, RJ, Brazil

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2022年 / 175卷

关键词：

Drug delivery system; Oral sustained release; Pharmaceutics design; Molecular modeling; Molecular dynamics simulations; DRUG-DELIVERY; FORCE-FIELD; MECHANISMS; TABLETS; SILICA; CLAYS;

D O I：

10.1016/j.ejps.2022.106222

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The drug delivery systems are an important strategy of pharmaceutical technology to modulate undesirable properties, increasing efficacy, and reducing the side effects of active pharmaceutical ingredients (API). The sustained release is a type of controlled-release system that provides a suitable drug level in the blood through a slow release rate. An interesting alternative to achieve a controlled release is the application of carrier materials such as polymers, cyclodextrins, and clays. Sodium montmorillonite (Na-MMT) is a biocompatible natural clay that allows the insertion of organic compounds in interlamellar space, owing to its high cation exchange capacity and large internal surface area. Bromopride (BPD) is an aminated compound with antiemetic properties classified as class II (low solubility, high permeability) of the Biopharmaceutical Classification System (BCS). Herein, the aim of the study was the development and investigation of a drug delivery system formed by intercalation of BPD with Na-MMT. The results indicate the successful intercalation of this API with the lamellar silicate, meanwhile, there was no evidence of BPD intercalation in organic montmorillonite. The Na-MMT/BPD molecular complex exhibits a sustained release in performed assays. Molecular dynamics simulations suggested that BPD molecules interact with the montmorillonite layer through ion-dipole interactions and also between BPD molecules, forming hydrogen bonds web into montmorillonite interlayer space. The new drug delivery system showed an alternative to achieve the BPD sustained release, which may improve its pharmacological performance in therapeutic applications.

引用

页数：16

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