Antitumor activity of ZD6474, a potent inhibitor of vascular endothelial growth factor signaling and epidermal growth factor, in the metastatic orthotopic brain tumor model

被引：0
|
作者：
Kong, Doo-Slk [1 ]
Jeon, Ji-Won [1 ]
Jeon, Hyun jung [1 ]
Nam, Do-Hyun [1 ]
机构：
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg,Samsung Biomed Res Inst, Seoul, South Korea
来源：
CLINICAL & EXPERIMENTAL METASTASIS | 2007年 / 24卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：312 / 313
页数：2
相关论文
共 50 条
  • [1] Antitumor activity of ZD6474 in a metastatic orthotopic brain tumor model
    Kong, Doo-Sik
    Kim, Mi-Hyun
    Jeon, Ji-Won
    Kim, Shi-Yeon
    Kim, Maeng Sup
    Joo, Kyeung Min
    Park, Kwan
    Nam, Do-Hyun
    MOLECULAR MEDICINE REPORTS, 2008, 1 (03) : 343 - 346
  • [2] ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: Schedule-dependent enhancement of antitumor activity
    Williams, KJ
    Telfer, BA
    Brave, S
    Kendrew, J
    Whittaker, L
    Stratford, IJ
    Wedge, SR
    CLINICAL CANCER RESEARCH, 2004, 10 (24) : 8587 - 8593
  • [3] Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer
    Bianco, Cataldo
    Giovannetti, Elisa
    Ciardiello, Fortunato
    Mey, Valentina
    Nannizzi, Sara
    Tortora, Giampaolo
    Troiani, Teresa
    Pasqualetti, Francesco
    Eckhardt, Gail
    de Liguoro, Mario
    Ricciardi, Simona
    Del Tacca, Mario
    Raben, David
    Cionini, Luca
    Danesi, Romano
    CLINICAL CANCER RESEARCH, 2006, 12 (23) : 7099 - 7107
  • [4] ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    Wedge, SR
    Ogilvie, DJ
    Dukes, M
    Kendrew, J
    Chester, R
    Jackson, JA
    Boffey, SJ
    Valentine, PJ
    Curwen, JO
    Musgrove, HL
    Graham, GA
    Hughes, GD
    Thomas, AP
    Stokes, ESE
    Curry, B
    Richmond, GHP
    Wadsworth, PF
    Bigley, AL
    Hennequin, LF
    CANCER RESEARCH, 2002, 62 (16) : 4645 - 4655
  • [5] Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model
    Conrad, Claudius
    Ischenko, Ivan
    Koehl, Gudrun
    Wiegand, Ulrich
    Guba, Markus
    Yezhelyev, Maksim
    Ryan, Anderson J.
    Barge, Alan
    Geissler, Edward K.
    Wedge, Stephen R.
    Jauch, Karl-Walter
    Bruns, Christiane J.
    ANTI-CANCER DRUGS, 2007, 18 (05) : 569 - 579
  • [6] Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    Ciardiello, F
    Caputo, R
    Damiano, V
    Caputo, R
    Troiani, T
    Vitagliano, D
    Carlomagno, F
    Veneziani, BM
    Fontanini, G
    Bianco, AR
    Tortora, G
    CLINICAL CANCER RESEARCH, 2003, 9 (04) : 1546 - 1556
  • [7] ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and angiogenesis of gastric cancer
    McCarty, MF
    Wey, J
    Stoeltzing, O
    Liu, WB
    Fan, F
    Bucana, C
    Mansfield, PF
    Ryan, AJ
    Ellis, LM
    MOLECULAR CANCER THERAPEUTICS, 2004, 3 (09) : 1041 - 1048
  • [8] ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors
    Rich, JN
    Sathornsumetee, S
    Keir, ST
    Kieran, MW
    Laforme, A
    Kaipainen, A
    McLendon, RE
    Graner, MW
    Rasheed, BKA
    Wang, L
    Reardon, DA
    Ryan, AJ
    Wheeler, C
    Dimery, I
    Bigner, DD
    Friedman, HS
    CLINICAL CANCER RESEARCH, 2005, 11 (22) : 8145 - 8157
  • [9] Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy
    Ciardiello, F
    Bianco, R
    Caputo, R
    Caputo, R
    Damiano, V
    Troiani, T
    Melisi, D
    De Vita, F
    De Placido, S
    Bianco, AR
    Tortora, G
    CLINICAL CANCER RESEARCH, 2004, 10 (02) : 784 - 793
  • [10] Antitumor activity of ZD6474, a vascular endothelial growth factor-2 and epidermal growth factor receptor small molecule tyrosine kinase inhibitor, in combination with SC-236, a cyclooxygenase-2 inhibitor
    Tuccillo, C
    Romano, M
    Troiani, T
    Martinelli, E
    Morgillo, F
    De Vita, F
    Bianco, R
    Fontanini, G
    Bianco, RA
    Tortora, G
    Ciardiello, F
    CLINICAL CANCER RESEARCH, 2005, 11 (03) : 1268 - 1276
12345