Red blood cell distribution width and atrial fibrillation in patients with sick sinus syndrome

被引:18
作者
Korantzopoulos, Panagiotis [1 ]
Kyrlas, Konstantinos [1 ]
Liu, Tong [2 ]
Li, Guangping [2 ]
Goudevenos, John A. [1 ]
机构
[1] Univ Ioannina, Sch Med, Dept Cardiol 1, Stavrou Niarchou 1, Ioannina 45221, Greece
[2] Tianjin Med Univ, Hosp 2, Tianjin Inst Cardiol, Dept Cardiol, Tianjin, Peoples R China
关键词
Sinus node disease; Tachy-brady syndrome; Atrial fibrillation; Red cell distribution width; NODE DYSFUNCTION; ATHEROSCLEROSIS RISK; OXIDATIVE STRESS; ESC GUIDELINES; CANINE MODEL; ASSOCIATION; INTERVAL; DISEASE; LEVEL;
D O I
10.1016/j.jjcc.2015.07.013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Sick sinus syndrome (SSS) is associated with atrial fibrillation (AF). Red blood cell distribution width (RDW) is a marker of anisocytosis of erythrocytes and is related to inflammatory stress. Recently, RDW has been associated with AF. The aim of the present study was to evaluate the potential association of RDW with AF history in patients with SSS. Methods: Consecutive patients with symptomatic SSS undergoing dual-chamber pacemaker implantation were screened. Baseline clinical, laboratory, echocardiographic, and electrocardiographic parameters were recorded. Conventional inflammatory indexes were also assessed. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis for parameters associated with AF were performed. Results: The final study population consisted of 101 patients (47 men); median age: 77 [73-82] years. The demographic and clinical characteristics were comparable between tachy-brady (AF history) patients (n = 32) and patients with other forms of SSS (n = 69). Left atrial diameter was increased in tachy-brady patients [44 (39-48) mm vs. 39 (36-44) mm; p = 0.05]. Also, the RDW was greater in these patients [14.7 (13.6-15.4)% vs. 13.7 (13.4-14.3)%; p = 0.02]. Multivariate analysis showed that RDW is independently associated with AF (OR: 1.58; 95% CI: 1.06-2.85; p = 0.04). The ROC curve analysis showed that the area under the curve was 0.69 (p = 0.028). A RDW cut-off point of 14 was related to AF with a sensitivity of 70% and a specificity of 69%. Conclusion: RDW is associated with AF history in patients with SSS. The prognostic value of RDW in terms of future AF development and arrhythmia perpetuation in these patients should be further examined. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:551 / 554
页数:4
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