Lysosomes in cancer - living on the edge (of the cell)

被引：96

作者：

Hamalisto, Saara ^{[1
]}

Jaattela, Marja ^{[1
]}

机构：

[1] Danish Canc Soc, Res Ctr, Ctr Autophagy Recycling & Dis, Cell Death & Metab Unit, Copenhagen, Denmark

来源：

CURRENT OPINION IN CELL BIOLOGY | 2016年 / 39卷

基金：

新加坡国家研究基金会; 欧洲研究理事会;

关键词：

FOCAL ADHESION DYNAMICS; ACID SPHINGOMYELINASE; SPATIAL-DISTRIBUTION; CATHEPSIN-B; MEMBRANE PERMEABILIZATION; BREAST-CANCER; RAB7; EFFECTOR; MIGRATION; INVASION; TRAFFICKING;

D O I：

10.1016/j.ceb.2016.02.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The lysosomes have definitely polished their status inside the cell. Being discovered as the last resort of discarded cellular biomass, the steady rising of this versatile signaling organelle is currently ongoing. This review discusses the recent data on the unconventional functions of lysosomes, focusing mainly on the less studied lysosomes residing in the cellular periphery. We emphasize our discussion on the emerging paths the lysosomes have taken in promoting cancer progression to metastatic disease. Finally, we address how the altered cancerous lysosomes in metastatic cancers may be specifically targeted and what are the pending questions awaiting for elucidation.

引用

页码：69 / 76

页数：8

共 69 条

[11] Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes [J].

Caviston, Juliane P. ;

Zajac, Allison L. ;

Tokito, Mariko ;

Holzbaur, Erika L. F. .

MOLECULAR BIOLOGY OF THE CELL, 2011, 22 (04) :478-492

[12] Rab36 regulates the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34 [J].

Chen, Li ;

Hu, Jingjie ;

Yun, Ye ;

Wang, Tuanlao .

MOLECULAR MEMBRANE BIOLOGY, 2010, 27 (01) :23-30

[13] Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells [J].

Commisso, Cosimo ;

Davidson, Shawn M. ;

Soydaner-Azeloglu, Rengin G. ;

Parker, Seth J. ;

Kamphorst, Jurre J. ;

Hackett, Sean ;

Grabocka, Elda ;

Nofal, Michel ;

Drebin, Jeffrey A. ;

Thompson, Craig B. ;

Rabinowitz, Joshua D. ;

Metallo, Christian M. ;

Vander Heiden, Matthew G. ;

Bar-Sagi, Dafna .

NATURE, 2013, 497 (7451) :633-+

[14] Recent Insights into the Structure, Regulation, and Function of the V-ATPases [J].

Cotter, Kristina ;

Stransky, Laura ;

McGuire, Christina ;

Forgac, Michael .

TRENDS IN BIOCHEMICAL SCIENCES, 2015, 40 (10) :611-622

[15] The lysosome turns fifty [J].

de Duve, C .

NATURE CELL BIOLOGY, 2005, 7 (09) :847-849

[16] Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression [J].

Dozynkiewicz, Marta A. ;

Jamieson, Nigel B. ;

MacPherson, Iain ;

Grindlay, Joan ;

van den Berghe, Peter V. E. ;

von Thun, Anne ;

Morton, Jennifer P. ;

Gourley, Charlie ;

Timpson, Paul ;

Nixon, Colin ;

McKay, Colin J. ;

Carter, Ross ;

Strachan, David ;

Anderson, Kurt ;

Sansom, Owen J. ;

Caswell, Patrick T. ;

Norman, Jim C. .

DEVELOPMENTAL CELL, 2012, 22 (01) :131-145

[17] Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease [J].

Erie, Christine ;

Sacino, Matthew ;

Houle, Lauren ;

Lu, Michael L. ;

Wei, Jianning .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2015, 42 (03) :1941-1951

[18] The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis [J].

Eriksson, I. ;

Joosten, M. ;

Roberg, K. ;

Ollinger, K. .

EXPERIMENTAL CELL RESEARCH, 2013, 319 (01) :12-20

[19] At the acidic edge: emerging functions for lysosomal membrane proteins [J].

Eskelinen, EL ;

Tanaka, Y ;

Saftig, P .

TRENDS IN CELL BIOLOGY, 2003, 13 (03) :137-145

[20] Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2 [J].

Fehrenbacher, Nicole ;

Bastholm, Lone ;

Kirkegaard-Sorensen, Thomas ;

Rafn, Bo ;

Bottzauw, Trine ;

Nielsen, Christina ;

Weber, Ekkehard ;

Shirasawa, Senji ;

Kallunki, Tuula ;

Jaattela, Marja .

CANCER RESEARCH, 2008, 68 (16) :6623-6633

← 1 2 3 4 5 6 7 →