Lysosomes in cancer - living on the edge (of the cell)

被引:96
作者
Hamalisto, Saara [1 ]
Jaattela, Marja [1 ]
机构
[1] Danish Canc Soc, Res Ctr, Ctr Autophagy Recycling & Dis, Cell Death & Metab Unit, Copenhagen, Denmark
基金
新加坡国家研究基金会; 欧洲研究理事会;
关键词
FOCAL ADHESION DYNAMICS; ACID SPHINGOMYELINASE; SPATIAL-DISTRIBUTION; CATHEPSIN-B; MEMBRANE PERMEABILIZATION; BREAST-CANCER; RAB7; EFFECTOR; MIGRATION; INVASION; TRAFFICKING;
D O I
10.1016/j.ceb.2016.02.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The lysosomes have definitely polished their status inside the cell. Being discovered as the last resort of discarded cellular biomass, the steady rising of this versatile signaling organelle is currently ongoing. This review discusses the recent data on the unconventional functions of lysosomes, focusing mainly on the less studied lysosomes residing in the cellular periphery. We emphasize our discussion on the emerging paths the lysosomes have taken in promoting cancer progression to metastatic disease. Finally, we address how the altered cancerous lysosomes in metastatic cancers may be specifically targeted and what are the pending questions awaiting for elucidation.
引用
收藏
页码:69 / 76
页数:8
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