The prone position in acute respiratory distress syndrome: a critical systematic review

Objective. - To do a critical systematic review regarding effects of prone positioning (PP) in patients with acute respiratory distress syndrome (ARDS). Methods. - A systematic review (Highwire, Medline, Cochrane Library from 1976 to 2004), using the keywords: prone position, acute respiratory distress syndrome, allowed us to include the human studies on. PP in ARDS patients, independantly of their objectives or their type of protocol. To appreciate the studies validity, we scored the quality evidence of the studies in order to grade our conclusions. Results and conclusion. - The qualitative analysis of the 58 included studies (1,500 patients returned prone, 4,00.0 episodes of PP) led to the following main conclusions: 1) the PP improves oxygenation in the majority of ARDS patients (level of evidence I); 2) the PP improves the pulmonary haemodynamics without altering the systemic haemodynamics (level of evidence III); 3) the PP enhances the recruitment maneuvers (level of evidence III); 4) because there are no formal predictive criteria for response to the PP, a "trial of PP." or better two PP trials are necessary to look for the responders; 5) the PP should be performed as early as possible in the course of severe ARDS; 6) the optimal duration of PP is 18 to 23 hours daily, and it should be continued until improvement of arterial oxygenation, or loss of the positive effect of PP on arterial oxygenation or evidently patient's death. (c) 2007 Elsevier Masson SAS. Tous droits reserves.