Wnt signaling in lung development, regeneration, and disease progression

被引：98

作者：

Aros, Cody J. ^{[1
,2
,3
]}

Pantoja, Carla J. ^{[3
]}

Gomperts, Brigitte N. ^{[3
,4
,5
,6
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol Biol, Interdept Program, Los Angeles, CA USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Med Scientist Training Program, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Childrens Discovery & Innovat Inst, Mattel Childrens Hosp,Dept Pediat, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Div Pulm & Crit Care Med, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA

[6] Univ Calif Los Angeles, Eli & Edythe Broad Stem Cell Res Ctr, Los Angeles, CA 90095 USA

来源：

COMMUNICATIONS BIOLOGY | 2021年 / 4卷 / 01期

关键词：

PLURIPOTENT STEM-CELLS; EPITHELIAL SELF-RENEWAL; BETA-CATENIN; SUBMUCOSAL GLAND; PROGENITOR CELLS; MOUSE LUNG; EFFICIENT DERIVATION; MULTICILIATED CELLS; LEF-1; EXPRESSION; AIRWAY EPITHELIA;

D O I：

10.1038/s42003-021-02118-w

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The respiratory tract is a vital, intricate system for several important biological processes including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling pathway plays several crucial and indispensable roles across lung biology in multiple contexts. This review highlights the progress made in characterizing the role of Wnt signaling across several disciplines in lung biology, including development, homeostasis, regeneration following injury, in vitro directed differentiation efforts, and disease progression. We further note uncharted directions in the field that may illuminate important biology. The discoveries made collectively advance our understanding of Wnt signaling in lung biology and have the potential to inform therapeutic advancements for lung diseases. Cody Aros, Carla Pantoja, and Brigitte Gomperts review the key role of Wnt signaling in all aspects of lung development, repair, and disease progression. They provide an overview of recent research findings and highlight where research is needed to further elucidate mechanisms of action, with the aim of improving disease treatments.

引用

页数：13

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