Angiotensin II type 1 receptor gene polymorphisms in humans: physiology and pathophysiology of the genotypes

被引：74

作者：

Duncan, JA ^{[1
]}

Scholey, JW ^{[1
]}

Miller, JA ^{[1
]}

机构：

[1] Univ Toronto, Dept Med, Toronto, ON, Canada

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2001年 / 10卷 / 01期

关键词：

D O I：

10.1097/00041552-200101000-00017

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Many studies have attempted to relate genetic variants of components of the renin-angiotensin system to complex diseases such as essential hypertension, cardiovascular disease and progressive renal failure. The angiotensin II type 1 receptor (AT(1)R) gene is an important example of this approach. Many polymorphisms of the AT(1)R gene have been identified, but the A(1166)-->C polymorphism has been the most extensively studied. The physiological significance of this polymorphism is uncertain because of its location in the 3'-untranslated region of the gene. The present review summarizes association studies of the AT(1)R gene, focusing on clinical end-points and physiological responses. Curr Opin Nephrol Hypertens 10:111-116. (C) 2001 Lippincott Williams & Wilkins.

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页码：111 / 116

页数：6

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