Semi-Automated Detection and Fractal Characterization of Myocardial Fibrosis in Histological Images

被引：0
作者：
Mayrhofer-Reinhartshuber, M. [1 ]
Kainz, P. [1 ]
Sanchez-Quintana, D. [2 ]
Macias, Y. [2 ]
Hofer, E. [1 ]
Ahammer, H. [1 ]
机构：
[1] Med Univ Graz, Inst Biophys, Graz, Austria
[2] Univ Extremadura, Dept Anat & Cell Biol, Badajoz, Spain
来源：
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK | 2014年 / 59卷
关键词：
D O I：
10.1515/bmt-2014-4253
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Histological images of 14 human hearts were analyzed by semi-automated image analysis. An image set of 40 images was used to quantify the amount of myocardial fibrosis caused by structural ischemic heart disease. Two different segmentation algorithms were tested and compared, both showing comparable results with statistically significant (p<0.001) differences between the investigated groups. Fractal image analysis using a new and efficient pyramid method was applied to the segmented images and revealed a fractal dimension of (1.65 +/- 0.10) for the investigated myocardial fibrosis, which is in the same range as results obtained by fractal characterization of liver fibrosis.
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页码：S587 / +
页数：4
相关论文
共 29 条
  • [1] IMAGE PYRAMIDS FOR CALCULATION OF THE BOX COUNTING DIMENSION
    Ahammer, H.
    Mayrhofer-Reinhartshuber, M.
    [J]. FRACTALS-COMPLEX GEOMETRY PATTERNS AND SCALING IN NATURE AND SOCIETY, 2012, 20 (3-4) : 281 - 293
  • [2] Image statistics and data mining of anal intraepithelial neoplasia
    Ahammer, H.
    Kroepfl, J. M.
    Hackl, Ch.
    Sedivy, R.
    [J]. PATTERN RECOGNITION LETTERS, 2008, 29 (16) : 2189 - 2196
  • [3] Ahammer H., 2009, MAYRHOFER REINHARTSH
  • [4] ISOLATION, CHARACTERIZATION, AND LOCALIZATION OF CARDIAC COLLAGEN TYPE-VI - ASSOCIATIONS WITH OTHER EXTRACELLULAR-MATRIX COMPONENTS
    BASHEY, RI
    MARTINEZHERNANDEZ, A
    JIMENEZ, SA
    [J]. CIRCULATION RESEARCH, 1992, 70 (05) : 1006 - 1017
  • [5] Cardiac fibroblasts: friend or foe?
    Baudino, Troy A.
    Carver, Wayne
    Giles, Wayne
    Borg, Thomas K.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 291 (03): : H1015 - H1026
  • [6] Continuous and discontinuous propagation in heart muscle
    de Bakker, JMT
    van Rijen, HMV
    [J]. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2006, 17 (05) : 567 - 573
  • [7] Monitoring cardiac fibrosis: a technical challenge
    de Jong, S.
    van Veen, T. A. B.
    de Bakker, J. M. T.
    van Rijen, H. V. M.
    [J]. NETHERLANDS HEART JOURNAL, 2012, 20 (01) : 44 - 48
  • [8] Fibrosis and Cardiac Arrhythmias
    de Jong, Sanne
    van Veen, Toon A. B.
    van Rijen, Harold V. M.
    de Bakker, Jacques M. T.
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2011, 57 (06) : 630 - 638
  • [9] Di Giovanni P., 2012, BIOL CORRELATES MACR
  • [10] Prediction of All-Cause Mortality and Heart Failure Admissions From Global Left Ventricular Longitudinal Strain in Patients With Acute Myocardial Infarction and Preserved Left Ventricular Ejection Fraction
    Ersboll, Mads
    Valeur, Nana
    Mogensen, Ulrik Madvig
    Andersen, Mads Jonsson
    Moller, Jacob Eifer
    Velazquez, Eric J.
    Hassager, Christian
    Sogaard, Peter
    Kober, Lars
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (23) : 2365 - 2373
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