Cancer, type 2 diabetes, and ageing: news from flies and worms

被引：0
作者：
Hafen, E [1 ]
机构：
[1] Univ Zurich, Inst Zool, CH-8057 Zurich, Switzerland
来源：
SWISS MEDICAL WEEKLY | 2004年 / 134卷 / 49-50期
关键词：
Drosophila; insulin; TOR; development; body size;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The turnout suppressor gene PTEN is, next to p53, the second most frequently mutated gene in human cancers. The genes TSC1 and TSC2 are mutated in the severe human syndrome called Tuberous Sclerosis. Patients with this disease have large benign tumours composed of large cells in the brain. The genetic dissection of pathways controlling the growth of cells, organs, and the entire organism in Drosophila has contributed to the understanding of the signalling pathways that are controlled by these two turnout suppressors. Together with, studies on nutrient regulation of growth and ageing in the nematode Caenorhabditis elegans, evidence from these model organisms has moved the Insulin/IGF (IIS) and the Target Rapamycin (TOR) signalling pathway onto the centre stage of cellular growth control and made them attractive novel targets for cancer therapy. In this review, I will outline the contributions of model organism genetics to the understanding of these disease relevant pathways and highlight the evolutionary conservation of nutrient-dependent growth regulation.
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收藏
页码：711 / 719
页数：9
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