Antiviral potential of a diterpenoid compound sugiol from Metasequoia glyptostroboides

被引：0

作者：

Bajpai, Vivek K. ^{[1
]}

Kim, Na-Hyung ^{[2
]}

Kim, Kangmin ^{[3
]}

Kang, Sun Chul ^{[4
]}

机构：

[1] Yeungnam Univ, Sch Biotechnol, Dept Appl Microbiol & Biotechnol, Gyongsan, South Korea

[2] Wonkwang Univ, Dept Oriental Pharm, Iksan, Jeonbuk, South Korea

[3] Chonbuk Natl Univ, Div Biotechnol, Coll Environm & Bioresource Sci, Joellabuk Do, Jeonbuk, South Korea

[4] Daegu Univ, Coll Engn, Dept Biotechnol, Gyongsan, Gyeongbuk, South Korea

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2016年 / 29卷 / 03期

关键词：

Sugiol; diterpenoid; antiviral effect; H1N1 influenza virus; MIKI EX HU; INFLUENZA-VIRUS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This research reports first time antiviral activity of sugiol, a diterpenoid isolated from Metasequoia glyptostroboides in terms of its ability to inhibit in vitro growth of H1N1 influenza virus. Antiviral potential of sugiol was evaluated through cytopathogenic reduction assay using Madin-Darby canine kidney (MDCK) cell line. Sugiol (500 mu g/ml) was found to exhibit considerable anti-cytopathic effect on MDCK cell line confirming its antiviral efficacy against H1N1 influenza virus. These findings strongly reinforce the suggestion that sugiol could be a candidate of choice in combinational regimen with potential antiviral efficacy.

引用

页码：1077 / 1080

页数：4

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