Antimutagenic activity of ent-kaurane diterpenoids from the aerial parts of Isodon japonicus

被引：16

作者：

Matsumoto, Takahiro ^{[1
]}

Nakamura, Seikou ^{[1
]}

Kojima, Naoto ^{[1
]}

Hasei, Tomohiro ^{[1
]}

Yamashita, Masayuki ^{[1
]}

Watanabe, Tetsushi ^{[1
]}

Matsuda, Hisashi ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Misasagi Shichono Cho 1, Kyoto 6078412, Japan

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 36期

关键词：

Isodon japonicus; ent-Kaurane diterpene; Isodonterpene; Antimutagenic activity; FLOWER BUDS; ABSOLUTE-CONFIGURATION; TERPENOIDS; RUBESCENS;

D O I：

10.1016/j.tetlet.2017.07.106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

From the methanolic extract of the aerial parts of Isodon japonicus, two new ent-kaurane diterpenes, isodonterpenes I and II, were isolated together with 10 known diterpenes. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The absolute configuration of isodonterpene I was elucidated by Cu-K alpha X-ray crystallographic analysis. Antimutagenic activities of the major diterpenes were evaluated by the Ames test. This study represents the first evaluation of the antimutagenic activities of ent-kaurane diterpenes. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：3574 / 3578

页数：5

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