Evaluation of anti-inflammatory, immunomodulatory, chemopreventive and wound healing potentials from Schinus terebinthifolius methanolic extract

被引：22

作者：

Fedel-Miyasato, Lis E. S. ^{[1
,2
]}

Kassuya, Candida A. L. ^{[3
]}

Auharek, Sarah A. ^{[4
,5
]}

Formagio, Anelise S. N. ^{[6
]}

Cardoso, Claudia A. L. ^{[7
]}

Mauro, Mariana O. ^{[2
]}

Cunha-Laura, Andrea L. ^{[1
]}

Monreal, Antonio C. D. ^{[1
]}

Vieira, Maria C. ^{[6
]}

Oliveira, Rodrigo J. ^{[1
,2
,4
]}

机构：

[1] Univ Fed Mato Grosso do Sul, Ctr Ciencias Biol & Saude, Campo Grande, MS, Brazil

[2] Univ Fed Mato Grosso do Sul, Nucleo Hosp Univ, Ctr Estudos Celulas Tronco Terapia Celular & Gene, Campo Grande, MS, Brazil

[3] Fundacao Univ Fed Grande Dourados, Fac Ciencias Saude, Dourados, MS, Brazil

[4] Univ Fed Mato Grosso do Sul, Fac Med, Programa Posgrad Saude & Desenvolvimento Regiao C, Campo Grande, MS, Brazil

[5] Univ Fed Vales Jequitinhonha & Mucuri, Fac Med Mucuri, Teofilo Otoni, MG, Brazil

[6] Fundacao Univ Fed Grande Dourados, Fac Ciencias Agr, Dourados, MS, Brazil

[7] Univ Estadual Mato Grosso do Sul, Curso Quim, Dourados, MS, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2014年 / 24卷 / 05期

关键词：

Schinus terebinthifolius; Inflammation; Immunomodulation; Micronucleus; Comet assay; ESSENTIAL OIL; RADDI; EXPRESSION; PLANTS;

D O I：

10.1016/j.bjp.2014.08.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inflammatory and genetic alterations are related to the development of chronic diseases such as cancer. Schinus terebinthifolius Raddi, Anacardiaceae, is used in folk medicine to treat inflammation, wounds and tumors. This study evaluated the anti-inflammatory, immunomodulatory, chemopreventive, and wound healing potentials of the methanolic extract from the leaves of Schinus terebinthifolius. The chemical composition of the extract was characterized using preliminary analytical LC methods. The results showed that the anti-inflammatory activity of the methanolic extract was similar to that of dexamethasone for edema reduction. Also, it inhibited the leukocyte migration into the air pouch and decreased plasma extravasation. In addition, the methanolic extract showed a healing action similar to that observed with collagenase. The methanolic extract is not genotoxic nor mutagenic, and in contrast it has chemopreventive activity, which elicits a high percentage of damage reduction by comet and micronucleus assay, preferably by bioantimutagenic action. The methanolic extract induced apoptosis and enhanced splenic phagocytosis in animals treated with cyclophosphamide. The methanolic extract contents, resolved by LC, include phenolic acid and flavonoids. Our results suggest a therapeutic potential for the methanolic extract. (C) 2014 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.

引用

页码：565 / 575

页数：11

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