Thioredoxin and thioredoxin reductase: Current research with special reference to human disease

被引：458

作者：

Holmgren, Arne ^{[1
]}

Lu, Jun ^{[1
]}

机构：

[1] Karolinska Inst, Div Biochem, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 396卷 / 01期

基金：

瑞典研究理事会;

关键词：

Thioredoxin; Thioredoxin reductase; Redox regulation; Thiol; Disulfide; Selenocysteine; MOLECULAR-MECHANISM; INHIBITION; EXPRESSION; CATALYSIS; OXIDATION;

D O I：

10.1016/j.bbrc.2010.03.083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thioredoxin (Trx) and thioredoxin reductase (TrxR) plus NADPH, comprising the thioredoxin system, has a large number of functions in DNA synthesis, defense against oxidative stress and apoptosis or redox signaling with reference to many diseases. All three isoenzymes of mammalian TrxR contain an essential selenocysteine residue, which is the target of several drugs in cancer treatment or mercury intoxication. The cytosolic Trx1 acting as the cells' protein disulfide reductase is itself reversibly redox regulated via three structural Cys residues. The evolution of mammalian Trx system compared to its prokaryotic counterparts may be an adaptation to the use of hydrogen peroxide and nitric oxide in redox regulation and signal transduction. (C) 2010 Elsevier Inc. All rights reserved.

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页码：120 / 124

页数：5

相关论文

共 43 条

[1] Focus on mammalian thioredoxin reductases - Important selenoproteins with versatile functions [J].

Arner, Elias S. J. .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2009, 1790 (06) :495-526

[2] Molecular Mechanisms of Thioredoxin and Glutaredoxin as Hydrogen Donors for Mammalian S Phase Ribonucleotide Reductase [J].

Avval, Farnaz Zahedi ;

Holmgren, Arne .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (13) :8233-8240

[3]

Baker A, 1997, CANCER RES, V57, P5162

[4] Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins [J].

Benhar, Moran ;

Forrester, Michael T. ;

Hess, Douglas T. ;

Stamler, Jonathan S. .

SCIENCE, 2008, 320 (5879) :1050-1054

[5] Inhibition of the human thioredoxin system - A molecular mechanism of mercury toxicity [J].

Carvalho, Cristina M. L. ;

Chew, Eng-Hui ;

Hashemy, Seyed Isaac ;

Lu, Jun ;

Holmgren, Arne .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (18) :11913-11923

[6] Thioredoxin-interacting protein -: A critical link between glucose toxicity and β-cell apoptosis [J].

Chen, Junqin ;

Saxena, Geetu ;

Mungrue, Inlran N. ;

Lusis, Aldons J. ;

Shalev, Anath .

DIABETES, 2008, 57 (04) :938-944

[7] An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling [J].

Damdimopoulos, AE ;

Miranda-Vizuete, A ;

Treuter, E ;

Gustafsson, JÅ ;

Spyrou, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (37) :38721-38729

[8] Thioredoxin reductase is irreversibly modified by curcumin - A novel molecular mechanism for its anticancer activity [J].

Fang, JG ;

Lu, J ;

Holmgren, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (26) :25284-25290

[9] The Thioredoxin-like Protein Rod-derived Cone Viability Factor (RdCVFL) Interacts with TAU and Inhibits Its Phosphorylation in the Retina [J].

Fridlich, Ram ;

Delalande, Francois ;

Jaillard, Celine ;

Lu, Jun ;

Poidevin, Laetitia ;

Cronin, Therese ;

Perrocheau, Ludivine ;

Millet-Puel, Geraldine ;

Niepon, Marie-Laure ;

Poch, Olivier ;

Holmgren, Arne ;

Van Dorsselaer, Alain ;

Sahel, Jose-Alain ;

Leveillard, Thierry .

MOLECULAR & CELLULAR PROTEOMICS, 2009, 8 (06) :1206-1218

[10] The thioredoxin system - From science to clinic [J].

Gromer, S ;

Urig, S ;

Becker, K .

MEDICINAL RESEARCH REVIEWS, 2004, 24 (01) :40-89

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