Peripheral Purinergic Receptor Modulation Influences the Trigeminal Ganglia Nitroxidergic System in an Experimental Murine Model of Inflammatory Orofacial Pain

被引：17
作者：
Borsani, Elisa [1 ]
Albertini, Roberta [1 ]
Labanca, Mauro [1 ,2 ]
Lonati, Claudio [1 ]
Rezzani, Rita [1 ]
Rodella, Luigi F. [1 ]
机构：
[1] Univ Brescia, Div Human Anat, Dept Biomed Sci & Biotechnol, I-25123 Brescia, Italy
[2] Univ Vita Salute San Raffaele, Dept Dent, Milan, Italy
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 2010年 / 88卷 / 12期
关键词：
purinergic receptors; trigeminal system; nitroxidergic system; inflammatory pain; mice; NITRIC-OXIDE SYNTHASE; 1-(2-TRIFLUOROMETHYLPHENYL) IMIDAZOLE TRIM; FOS-LIKE IMMUNOREACTIVITY; CYCLIC-GMP PATHWAY; C-FOS; NOCICEPTIVE RESPONSES; NUCLEUS CAUDALIS; SENSORY COMPLEX; ZIF/268; EXPRESSION; EXTRACELLULAR ATP;
D O I：
10.1002/jnr.22420
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
ATP plays an important role as an endogenous pain mediator generating and/or modulating pain signaling from the periphery to the central nervous system. The aim of this study was to analyze the role of peripheral purinergic receptors in modulation of the nitroxidergic system at a trigeminal ganglia level by monitoring changes in nitric oxide synthase isoforms. We also evaluated Fos-positive neurons in brainstem (spinal trigeminal nucleus) and pain-related behavior. We found that local administration of the P2 purinergic receptor antagonist pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) decreased face-rubbing activity, nitric oxide synthase isoform expression in trigeminal ganglia, and Fos expression in spinal trigeminal nucleus after subcutaneous injection of formalin. These results suggest a role for peripheral P2 purinergic receptors in orofacial pain transmission through modulation of the nitroxidergic system. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码：2715 / 2726
页数：12
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