Simple Model Study of Phase Transition Properties of Isolated and Aggregated Protein

被引：1
|
作者：
Ji, Yong-Yun [1 ]
Yi, Wei-Qi [1 ]
Zhang, Lin-Xi [1 ,2 ]
机构：
[1] Wenzhou Univ, Dept Phys, Wenzhou 325035, Peoples R China
[2] Zhejiang Univ, Dept Phys, Hangzhou 310027, Zhejiang, Peoples R China
来源：
JOURNAL OF STATISTICAL PHYSICS | 2011年 / 142卷 / 05期
关键词：
Protein folding; Phase transition; Misfolding diseases; MOLECULAR-DYNAMICS; DENATURED STATE; LATTICE; PROPAGATION; BEHAVIOR; BARNASE; DIAGRAM; VIEW;
D O I：
10.1007/s10955-011-0148-4
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
We investigate the phase transition properties of isolated and aggregated protein by exhaustive numerical study in the confined conformation space with maximally compact lattice model. The study within the confined conformation space shows some general folding properties. Various sequences show different folding properties: two-state folding, three-state folding and prion-like folding behavior. We find that the aggregated protein holds a more evident transition than isolated one and the transition temperature is generally lower than that in isolated case.
引用
收藏
页码：975 / 983
页数：9
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