Chronic use of proton pump inhibitors: Is the risk of osteoporosis and fractures real?

被引：1

作者：

Marti-Cabrera, Miguel ^{[1
,2
]}

Marti-Masanet, Miguel ^{[1
]}

Esplugues, Juan V. ^{[1
,2
,3
]}

机构：

[1] Univ Valencia, Dept Farmacol, Fac Med & Odontol, E-46003 Valencia, Spain

[2] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Valencia, Spain

[3] Hosp Univ Dr Peset Aleixandre, Valencia, Spain

来源：

GASTROENTEROLOGIA Y HEPATOLOGIA | 2011年 / 34卷 / 04期

关键词：

PPI; calcium; toxicity; fractures; osteoporosis; inhibition of acid secretion; GASTRIC-ACID SECRETION; BONE-MINERAL DENSITY; L-LACTIC ACID; HIP FRACTURE; CALCIUM-ABSORPTION; RESORPTION; PHOSPHATE; OMEPRAZOLE; SAFETY; WOMEN;

D O I：

10.1016/j.gastrohep.2011.01.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Proton pump inhibitors (PPI) are one of the most widely used groups of drugs and their potential toxicity is periodically reviewed, emphasizing aspects originally considered secondary. The present review analyzes the physiological and pharmacological bases and the scarce clinical evidence for a potential association between the continued administration of PPI and the development of osteoporosis and bone fractures. Both disorders are clearly related to calcium homeostasis and are highly important in elderly patients due to their poor general prognosis and disabling consequences. (C) 2010 Elsevier Espana, S.L. All rights reserved.

引用

页码：271 / 277

页数：7

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