Chronic use of proton pump inhibitors: Is the risk of osteoporosis and fractures real?

被引：1
|
作者：
Marti-Cabrera, Miguel [1 ,2 ]
Marti-Masanet, Miguel [1 ]
Esplugues, Juan V. [1 ,2 ,3 ]
机构：
[1] Univ Valencia, Dept Farmacol, Fac Med & Odontol, E-46003 Valencia, Spain
[2] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Valencia, Spain
[3] Hosp Univ Dr Peset Aleixandre, Valencia, Spain
来源：
GASTROENTEROLOGIA Y HEPATOLOGIA | 2011年 / 34卷 / 04期
关键词：
PPI; calcium; toxicity; fractures; osteoporosis; inhibition of acid secretion; GASTRIC-ACID SECRETION; BONE-MINERAL DENSITY; L-LACTIC ACID; HIP FRACTURE; CALCIUM-ABSORPTION; RESORPTION; PHOSPHATE; OMEPRAZOLE; SAFETY; WOMEN;
D O I：
10.1016/j.gastrohep.2011.01.002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Proton pump inhibitors (PPI) are one of the most widely used groups of drugs and their potential toxicity is periodically reviewed, emphasizing aspects originally considered secondary. The present review analyzes the physiological and pharmacological bases and the scarce clinical evidence for a potential association between the continued administration of PPI and the development of osteoporosis and bone fractures. Both disorders are clearly related to calcium homeostasis and are highly important in elderly patients due to their poor general prognosis and disabling consequences. (C) 2010 Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：271 / 277
页数：7
相关论文
共 50 条
  • [21] Use of Proton Pump Inhibitors and risk of gastric cancer
    Karakan, Tarkan
    TURKISH JOURNAL OF GASTROENTEROLOGY, 2018, 29 (01): : 143 - 144
  • [22] Cumulative Use of Proton Pump Inhibitors and Risk of Dementia
    Northuis, Carin A.
    Bell, Elizabeth J.
    Lutsey, Pamela L.
    George, Kristen M.
    Gottesman, Rebecca F.
    Mosley, Tom H.
    Whitsel, Eric A.
    Lakshminarayan, Kamakshi
    NEUROLOGY, 2023, 101 (18) : E1771 - E1778
  • [23] Use of proton pump inhibitors for the risk of gastric cancer
    Gao, Huiqin
    Li, Lunan
    Geng, Ke
    Teng, Changzheng
    Chen, Yuanyuan
    Chu, Fei
    Zhao, Yi
    MEDICINE, 2022, 101 (49) : E32228
  • [24] Proton pump inhibitors use and risk of incident nephrolithiasis
    Sui, Wilson
    Miller, Nicole L.
    Gould, Edward R.
    Zhang, Kevin C.
    Koyama, Tatsuki
    Hsi, Ryan S.
    UROLITHIASIS, 2022, 50 (04) : 401 - 409
  • [25] Proton pump inhibitors use and risk of incident nephrolithiasis
    Wilson Sui
    Nicole L. Miller
    Edward R. Gould
    Kevin C. Zhang
    Tatsuki Koyama
    Ryan S. Hsi
    Urolithiasis, 2022, 50 : 401 - 409
  • [26] Association of Osteoporosis and Hip Fractures in Patients Who Use Proton Pump Inhibitors: A Multicenter Propensity Score Matching Analysis
    Ibrahim, Mounir
    El Telbany, Ahmed
    Mohamed, Islam
    Alchirazi, Khaled Alsabbagh
    Sarmini, Muhammad
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2024, 119 (10S): : S408 - S409
  • [27] Current Use of Proton Pump Inhibitors is Associated With an Increased Risk of Osteoporotic Fractures: A Meta-Analysis
    Tsoi, Kelvin K.
    Ng, Siew C.
    Wong, Martin C.
    Hirai, Hoyee W.
    Lam, Thomas
    Chan, Francis K. L.
    GASTROENTEROLOGY, 2011, 140 (05) : S210 - S210
  • [28] Use of proton pump inhibitors in patients with chronic liver disease
    Chavez-tapia, Norberto
    Tellez-avila, Felix
    Garcia-leyva, Jorge
    Valdovinos, Miguel A.
    GASTROENTEROLOGY, 2007, 132 (04) : A473 - A474
  • [29] The use of proton pump inhibitors is positively associated with osteoporosis in postmenopausal women in Germany
    Jacob, L.
    Hadji, P.
    Kostev, K.
    CLIMACTERIC, 2016, 19 (05) : 478 - 481
  • [30] PROTON PUMP INHIBITORS USE AND THE RISK OF CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW AND META ANALYSIS
    Hussain, Salman
    Singh, Ambrish
    Habib, Anwar
    Najmi, Abul Kalam
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2017, 32
12345