Avermectin loaded carboxymethyl cellulose nanoparticles with stimuli-responsive and controlled release properties

被引：49

作者：

Zhu, Huaxin ^{[1
]}

Shen, Yue ^{[1
]}

Cui, Jianxia ^{[1
]}

Wang, Anqi ^{[1
]}

Li, Ningjun ^{[1
]}

Wang, Chong ^{[1
]}

Cui, Bo ^{[1
]}

Sun, Changjiao ^{[1
]}

Zhao, Xiang ^{[1
]}

Wang, Chunxin ^{[1
]}

Gao, Fei ^{[1
]}

Zhan, Shenshan ^{[1
]}

Guo, Liang ^{[1
]}

Zhang, Liang ^{[1
]}

Zeng, Zhanghua ^{[1
]}

Wang, Yan ^{[1
]}

Cui, Haixin ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Inst Environm & Sustainable Dev Agr, Beijing 100081, Peoples R China

来源：

INDUSTRIAL CROPS AND PRODUCTS | 2020年 / 152卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Avermectin; Esterase-responsive; Nanoparticles; Anti-photodegradation; MESOPOROUS SILICA; ANTI-PHOTOLYSIS; PACLITAXEL; MICELLES; DELIVERY; CHITOSAN;

D O I：

10.1016/j.indcrop.2020.112497

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Polyethylene glycol (PEG) was introduced into carboxymethyl cellulose (CMC) to form hydrophilic chain of PEG-CMC. Avermectin (Avm) was grafted on the long chain of PEG-CMC by use of N, N-dicyclohexylcarbodiimide (DCC) as the dehydrant and 4-dimethylaminopyridine (DMAP) as the catalyst to form the amphiphilic molecule. Then the avermectin nanoparticles was prepared with esterase-responsive sustained release successfully through self-assembly. The size of nanoparticles was less than 400 nm. Avermectin loading was 8% and the degradation rate was less than 50 % under the xenon arc lamp for 72 h. Compared with avermectin technical, it showed an obvious anti-photodegradation advantage. Compared with commercially available water-dispersible granules (WDG), the avermectin nanoparticles had a smaller contact angle on the cucumber leaf surface and there was a significant difference. The toxicity test showed that the nanoparticles have a certain insecticidal effect on the larva of Hyphantria cunea and the sensitivity increased gradually over time.

引用

页数：7

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