DETERMINATION OF METHADONE IN HUMAN HAIR BY HEADSPACE EXTRACTION AND ION MOBILITY SPECTROMETRY

被引：5

作者：

Sheibani, Ali ^{[1
,2
]}

Tabrizchi, Mahmoud ^{[2
]}

Ghaziaskar, Hassan S. ^{[2
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Yazd Branch, Tehran 89195155, Iran

[2] Isfahan Univ Technol, Dept Chem, Esfahan, Iran

来源：

ANALYTICAL LETTERS | 2011年 / 44卷 / 04期

关键词：

Headspace extraction; Human hair; Ion mobility spectrometry; Methadone; MASS-SPECTROMETRY; QUANTITATIVE-ANALYSIS; MAIN METABOLITE; 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE; OPIATES; COCAINE; SPME; EDDP; GAS;

D O I：

10.1080/00032711003783069

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ion mobility spectrometry along with headspace extraction was used for the determination of methadone in human hair. The hair samples were digested in an extraction cell containing NaOH and NaCl. Then, headspace extraction and determination processes were continuously performed. The calibration curve was linear over a range of 0.20 to 25 ng mg(-1) with a correlation coefficient of 0.987. The limit of detection and the limit of quantitation were 0.01 and 0.03 ng mg(-1), respectively. The relative standard deviation and the extraction recovery were 8.7% and about 70%, respectively. The developed method was applied to the analysis of real samples.

引用

页码：667 / 675

页数：9

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