FOXM1 facilitates gastric cancer cell migration and invasion by inducing Cathepsin D

被引：3

作者：

Yang, Li ^{[1
]}

Cui, Ming ^{[2
]}

Zhang, Liang ^{[3
]}

Song, Lei ^{[3
]}

机构：

[1] Dalian Med Univ, Dept Intens Care Unit, Affiliated Hosp 2, Dalian 116027, Liaoning, Peoples R China

[2] Dalian Med Univ, Dept Emergency, Affiliated Hosp 2, Dalian 116027, Liaoning, Peoples R China

[3] Dalian Med Univ, Dept Intervent Therapy, Affiliated Hosp 2, Dalian 116027, Liaoning, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 40期

关键词：

FOXM1; Cath-D; gastric cancer; TRANSCRIPTION FACTORS; DOWN-REGULATION; BREAST-CANCER; FOXO3A; PROLIFERATION; RESISTANCE; APOPTOSIS; ROLES;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Forkhead box M1 (FOXM1) has been reported as a vital transcription factor in different human malignancies. To date, the mechanisms of FOXM1 in modulating the invasion and metastasis of gastric cancer cells have not been elucidated. In the present study, we found that overexpression of FOXM1 prompted cell migration and invasion of gastric cancer, and increased the expression of Cathepsin D (Cath-D). However, FOXM1 siRNA repressed cell migration and invasion, and also decreased the expression of Cath-D in gastric cancer cells. Blocking of Cath-D repressed FOXM1 overexpression-mediated cell migration and invasion. Mechanically, FOXM1 facilitated the activation of Cath-D promoter. Furthermore, overexpression of Cath-D affected the expression of E-cadherin, leading to epithelial-mesenchymal transition (EMT) of gastric cancer cells. In conclusion, this study demonstrated that FOXM1 promotes gastric cancer cell migration and invasion through inducing expression of Cath-D in gastric cancer. Thus, FOXM1 may be recommended as a potential therapeutic target for gastric cancer patients.

引用

页码：68180 / 68190

页数：11

共 24 条

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