Influence of Linker Molecules in Hexavalent RGD Peptides on Their Multivalent Interactions with Integrin αv3β

被引：10
|
作者：
Mizuno, Yuki [1 ,2 ,3 ]
Kimura, Kohta [1 ]
Onoe, Satoru [1 ]
Shukuri, Miho [1 ]
Kuge, Yuji [2 ,3 ]
Akizawa, Hiromichi [1 ]
机构：
[1] Showa Pharmaceut Univ, Lab Phys Chem, Machida, Tokyo 1948543, Japan
[2] Hokkaido Univ, Cent Inst Isotope Sci, Sapporo, Hokkaido 0600815, Japan
[3] Hokkaido Univ, Grad Sch Biomed Sci & Engn, Dept Biomed Imaging, Sapporo, Hokkaido 0608638, Japan
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 64卷 / 21期
关键词：
LIGANDS; BIVALENT; AVIDITY; PROBES;
D O I：
10.1021/acs.jmedchem.1c01396
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
'multivalent r)Deptideshavebeenusedasanexcellenttargetingvect tinteg11n(i33-Pcs1t1vetumors. Hu weve little attention has beenFa d to the influenceof linker muiecuiesinmlitivaentRGDPe:tides ntlelrdiss cat1 n(1nfr fromtumor thedissociatiun kinetics uL99 ic_iaheied hexava etRG1PePtideswhichhave(:H:-CH2 0) (n = 4 [9nrc]['c(l1)6]+ldn=12'[99nTc][Tcr'2\6]Tor()pt0-Gly)(n=i[99mTc][Te(L3\6]'1=6' 99mTcTc(L4)61+,and molecule.[9n iLTe(L:)] dtsplayedsl)erdiss clati nuneticsand[9mTc1 rL4/6+sI vedexcefti 1allYhighin1it!ocellIiarnptake (203.1+i6.700,,/lg protein}andtnehighesttumurt bi drati cl38.l 26.3 at 4 hP.1.) inthn rbear11gnu"emice.These findings indicate that the use ofaPproprlate length of (DPru-GlY)w0uidnwimizethe bludtng fmultivaiertRGDPePtidest clustered integrin avP_3-
引用
收藏
页码：16008 / 16019
页数：12
相关论文
共 50 条
  • [41] Radiolabeled Cyclic RGD Peptides as Integrin αvβ3-Targeted Radiotracers: Maximizing Binding Affinity via Bivalency
    Liu, Shuang
    BIOCONJUGATE CHEMISTRY, 2009, 20 (12) : 2199 - 2213
  • [42] 68Ga- and 111In-labelled DOTA-RGD peptides for imaging of αvβ3 integrin expression
    Decristoforo, Clemens
    Gonzalez, Ignacio Hernandez
    Carlsen, Janette
    Rupprich, Marco
    Huisman, Marc
    Virgolini, Irene
    Wester, Hans-Juergen
    Haubner, Roland
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2008, 35 (08) : 1507 - 1515
  • [43] 68Ga- and 111In-labelled DOTA-RGD peptides for imaging of αvβ3 integrin expression
    Clemens Decristoforo
    Ignacio Hernandez Gonzalez
    Janette Carlsen
    Marco Rupprich
    Marc Huisman
    Irene Virgolini
    Hans-Jürgen Wester
    Roland Haubner
    European Journal of Nuclear Medicine and Molecular Imaging, 2008, 35 : 1507 - 1515
  • [44] Vascular smooth muscle alpha v beta 3 integrin mediates vasodilation in response to RGD peptides and collagen fragments
    Mogford, JE
    Platts, SH
    Davies, GE
    Meininger, GA
    FASEB JOURNAL, 1996, 10 (03): : 3514 - 3514
  • [45] Click chemistry for 18F-labeling of RGD peptides and microPET Imaging of tumor integrin αvβ3 expression
    Li, Zi-Bo
    Wu, Zhanhong
    Chen, Kai
    Chin, Frederick T.
    Chen, Xiaoyuan
    BIOCONJUGATE CHEMISTRY, 2007, 18 (06) : 1987 - 1994
  • [46] Targeting Integrin αVβ3 with Theranostic RGD-Camptothecin Conjugates Bearing a Disulfide Linker: Biological Evaluation Reveals a Complex Scenario
    Pina, Arianna
    Dal Corso, A.
    Caruso, Michele
    Belvisi, Laura
    Arosio, Daniela
    Zanella, Simone
    Gasparri, Fabio
    Albanese, Clara
    Cucchi, Ulisse
    Fraietta, Ivan
    Marsiglio, Aurelio
    Pignataro, Luca
    Donati, Daniele
    Gennari, Cesare
    CHEMISTRYSELECT, 2017, 2 (17): : 4759 - 4766
  • [47] Novel cilengitide-based cyclic RGD peptides as ανβ3 integrin inhibitors
    Meena, Chhuttan L.
    Singh, Dharmendra
    Weinmueller, Michael
    Reichart, Florian
    Dangi, Abha
    Marelli, Udaya Kiran
    Zahler, Stefan
    Sanjayan, Gangadhar J.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (08)
  • [48] Comparison of Linear vs. Cyclic RGD Pentapeptide Interactions with Integrin αvβ3 by Molecular Dynamics Simulations
    Li, Na
    Qiu, Simei
    Fang, Ying
    Wu, Jianhua
    Li, Quhuan
    BIOLOGY-BASEL, 2021, 10 (07):
  • [49] Development of 99mTc-labeled hexavalent c(RGDfK) peptide with optimized linker structure for in vivo imaging of integrin a vß3
    Mizuno, Yuki
    Kimura, Kohta
    Onoe, Satoru
    Shukuri, Miho
    Kuge, Yuji
    Akizawa, Hiromichi
    NUCLEAR MEDICINE AND BIOLOGY, 2022, 114 : S7 - S8
  • [50] A new cyclic RGD peptide dimer for integrin αvβ3 imaging
    Ma, H.
    Hao, P.
    Zhang, L.
    Ma, C.
    Yan, P.
    Wang, R. -F.
    Zhang, C. -L.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2016, 20 (04) : 613 - 619
12345