Fatal enhanced respiratory syncytial virus disease in toddlers

被引:21
作者
Polack, Fernando P. [1 ,2 ]
Alvarez-Paggi, Damian [1 ,3 ]
Libster, Romina [1 ,3 ]
Caballero, Mauricio T. [1 ,3 ]
Blair, Robert, V [4 ]
Hijano, Diego R. [1 ,5 ]
de la Iglesia Niveyro, Paola X. [6 ]
Menendez, Daniel R. [7 ]
Gladwell, Wes [7 ]
Avendano, Luis M. [8 ]
Velozo, Luis [8 ]
Wanek, Alanna [4 ]
Bergel, Eduardo [9 ]
Prince, Gregory A.
Kleeberger, Steven R. [6 ]
Johnson, Joyce [2 ]
Pociask, Derek [4 ]
Kolls, Jay K. [4 ]
机构
[1] Fdn INFANT, Buenos Aires, DF, Argentina
[2] Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA
[3] Natl Sci & Tech Res Council CONICET, Buenos Aires, DF, Argentina
[4] Tulane Univ, New Orleans, LA 70118 USA
[5] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA
[6] Hosp Italiano Buenos Aires Argentina, Buenos Aires, DF, Argentina
[7] NIEHS, Raleigh, NC USA
[8] Univ Nacl Chile, Santiago, Chile
[9] Inst Efectividad Clin & Sanitaria, Buenos Aires, DF, Argentina
基金
比尔及梅琳达.盖茨基金会;
关键词
PULMONARY EOSINOPHILIA; VACCINE; IMMUNIZATION; ABSENCE; MODEL; RSV;
D O I
10.1126/scitranslmed.abj7843
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In 1967, two toddlers immunized with a formalin-inactivated vaccine against respiratory syncytial virus (FIRSV) in the United States died from enhanced RSV disease (ERD), a severe form of illness resulting from aberrant priming of the antiviral immune response during vaccination. Up to 80% of immunized children subsequently exposed to wild-type virus were hospitalized. These events hampered RSV vaccine development for decades. Here, we provide a characterization of the clinical, immunopathological, and transcriptional signature of fatal human ERD, outlining evidence for safety evaluation of RSV vaccines and a framework for understanding disease enhancement for pathogens in general.
引用
收藏
页数:6
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