Fatal enhanced respiratory syncytial virus disease in toddlers

被引：21

作者：

Polack, Fernando P. ^{[1
,2
]}

Alvarez-Paggi, Damian ^{[1
,3
]}

Libster, Romina ^{[1
,3
]}

Caballero, Mauricio T. ^{[1
,3
]}

Blair, Robert, V ^{[4
]}

Hijano, Diego R. ^{[1
,5
]}

de la Iglesia Niveyro, Paola X. ^{[6
]}

Menendez, Daniel R. ^{[7
]}

Gladwell, Wes ^{[7
]}

Avendano, Luis M. ^{[8
]}

Velozo, Luis ^{[8
]}

Wanek, Alanna ^{[4
]}

Bergel, Eduardo ^{[9
]}

Prince, Gregory A.

Kleeberger, Steven R. ^{[6
]}

Johnson, Joyce ^{[2
]}

Pociask, Derek ^{[4
]}

Kolls, Jay K. ^{[4
]}

机构：

[1] Fdn INFANT, Buenos Aires, DF, Argentina

[2] Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA

[3] Natl Sci & Tech Res Council CONICET, Buenos Aires, DF, Argentina

[4] Tulane Univ, New Orleans, LA 70118 USA

[5] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

[6] Hosp Italiano Buenos Aires Argentina, Buenos Aires, DF, Argentina

[7] NIEHS, Raleigh, NC USA

[8] Univ Nacl Chile, Santiago, Chile

[9] Inst Efectividad Clin & Sanitaria, Buenos Aires, DF, Argentina

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2021年 / 13卷 / 616期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

PULMONARY EOSINOPHILIA; VACCINE; IMMUNIZATION; ABSENCE; MODEL; RSV;

D O I：

10.1126/scitranslmed.abj7843

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In 1967, two toddlers immunized with a formalin-inactivated vaccine against respiratory syncytial virus (FIRSV) in the United States died from enhanced RSV disease (ERD), a severe form of illness resulting from aberrant priming of the antiviral immune response during vaccination. Up to 80% of immunized children subsequently exposed to wild-type virus were hospitalized. These events hampered RSV vaccine development for decades. Here, we provide a characterization of the clinical, immunopathological, and transcriptional signature of fatal human ERD, outlining evidence for safety evaluation of RSV vaccines and a framework for understanding disease enhancement for pathogens in general.

引用

页数：6

共 24 条

[1] TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization
Caballero, Mauricio T.
Serra, M. Elina
Acosta, Patricio L.
Marzec, Jacqui
Gibbons, Luz
Salim, Maximiliano
Rodriguez, Andrea
Reynaldi, Andrea
Garcia, Alejandro
Bado, Daniela
Buchholz, Ursula J.
Hijano, Diego R.
Coviello, Silvina
Newcomb, Dawn
Bellabarba, Miguel
Ferolla, Fausto M.
Libster, Romina
Berenstein, Ada
Siniawaski, Susana
Blumetti, Valeria
Echavarria, Marcela
Pinto, Leonardo
Lawrence, Andrea
Ossorio, M. Fabiana
Grosman, Arnoldo
Mateu, Cecilia G.
Bayle, Carola
Dericco, Alejandra
Pellegrini, Mariana
Igarza, Ignacio
Repetto, Horatio A.
Grimaldi, Luciano Alva
Gudapati, Prathyusha
Polack, Norberto R.
Althabe, Fernando
Shi, Min
Ferrero, Fernando
Berge, Eduardo
Stein, Renato T.
Peebles, R. Stokes
Boothby, Mark
Kleeberger, Steven R.
Polack, Fernando P.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (02) : 571 - 582
[2] FIELD EVALUATION OF A RESPIRATORY SYNCYTIAL VIRUS VACCINE AND A TRIVALENT PARAINFLUENZA VIRUS VACCINE IN A PEDIATRIC POPULATION
CHIN, J
MAGOFFIN, RL
SHEARER, LA
SCHIEBLE, JH
LENNETTE, EH
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1969, 89 (04) : 449 - +
[3] A proof of concept for structure-based vaccine design targeting RSV in humans
Crank, Michelle C.
Ruckwardt, Tracy J.
Chen, Man
Morabito, Kaitlyn M.
Phung, Emily
Costner, Pamela J.
Holman, LaSonji A.
Hickman, Somia P.
Berkowitz, Nina M.
Gordon, Ingelise J.
Yamshchikov, Galina V.
Gaudinski, Martin R.
Kumar, Azad
Chang, Lauren A.
Moin, Syed M.
Hill, Juliane P.
DiPiazza, Anthony T.
Schwartz, Richard M.
Kueltzo, Lisa
Cooper, Jonathan W.
Chen, Peifeng
Stein, Judith A.
Carlton, Kevin
Gall, Jason G.
Nason, Martha C.
Kwong, Peter D.
Chen, Grace L.
Mascola, John R.
McLellan, Jason S.
Ledgerwood, Julie E.
Graham, Barney S.
[J]. SCIENCE, 2019, 365 (6452) : 505 - +
[4] Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy
Drouin, SM
Corry, DB
Hollman, TJ
Kildsgaard, J
Wetsel, RA
[J]. JOURNAL OF IMMUNOLOGY, 2002, 169 (10) : 5926 - 5933
[5] Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease
Florencia Delgado, Maria
Coviello, Silvina
Clara Monsalvo, A.
Melendi, Guillermina A.
Zea Hernandez, Johanna
Batalle, Juan P.
Diaz, Leandro
Trento, Alfonsina
Chang, Herng-Yu
Mitzner, Wayne
Ravetch, Jeffrey
Melero, Jose A.
Irusta, Pablo M.
Polack, Fernando P.
[J]. NATURE MEDICINE, 2009, 15 (01) : 34 - 41
[6] Geoghegan S, 2017, AM J RESP CRIT CARE, V195, P96, DOI [10.1164/rccm.201603-0658oc, 10.1164/rccm.201603-0658OC]
[7] A bovine model of vaccine enhanced respiratory syncytial virus pathophysiology
Gershwin, LJ
Schelegle, ES
Gunther, RA
Anderson, ML
Woolums, AR
Larochelle, DR
Boyle, GA
Friebertshauser, KE
Singer, RS
[J]. VACCINE, 1998, 16 (11-12) : 1225 - 1236
[8] GRAHAM BS, 1993, J IMMUNOL, V151, P2032
[9] The histopathology of fatal untreated human respiratory syncytial virus infection
Johnson, Joyce E.
Gonzales, Ricardo A.
Olson, Sandy J.
Wright, Peter F.
Graham, Barney S.
[J]. MODERN PATHOLOGY, 2007, 20 (01) : 108 - 119
[10] Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma
Karp, CL
Grupe, A
Schadt, E
Ewart, SL
Keane-Moore, M
Cuomo, PJ
Köhl, J
Wahl, L
Kuperman, D
Germer, S
Aud, D
Peltz, G
Wills-Karp, M
[J]. NATURE IMMUNOLOGY, 2000, 1 (03) : 221 - 226

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