Monoolein cubic phases containing cinnamic acid, poly(ethyleneimine) and gold nanoparticle and their UV- and NIR-responsive release property

被引:4
|
作者
Park, Danbi
Kim, Jin-Chul [1 ]
机构
[1] Kangwon Natl Univ, Coll Biomed Sci, Dept Med Biomat Engn, Chunchon, South Korea
基金
新加坡国家研究基金会;
关键词
UV; NIR; Monoolein cubic phase; Poly(ethyleneimine); Cinnamic acid; Gold nanoparticle; BEHAVIOR; DIAGRAM;
D O I
10.1016/j.ijpharm.2018.06.044
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
UV and NIR-responsive monoolein cubic phase was prepared by including poly(ethyleneimine) (PEI)/cinnamic acid (CA) conjugate and gold nanoparticle (GNP) within its structure. UV irradiation elevated significantly the release % of Auramine O loaded in cubic phase containing PEI/CA, possibly because of the trans-to-cis isomerization of CA. NIR irradiation also increased significantly the release % of FITC-dextran loaded in cubic phase containing PEI/CA. The release % of the dye loaded in cubic phase containing PEI/CA and GNP was elevated more markedly by NIR irradiation, possibly due to the phase transition of cubic phase and the disassembling of PEI/CA assembly.
引用
收藏
页码:420 / 428
页数:9
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