Self-Assembly of DNA molecules in magnetic Fields

被引:1
|
作者
Gao, Mingyan [1 ,2 ]
Hu, Jing [1 ,2 ]
Wang, Jianfei [1 ,2 ]
Liu, Mengnan [1 ,2 ]
Zhu, Xiaona [1 ,2 ]
Saeed, Sadaf [1 ,2 ]
Hu, Cuihua [1 ,2 ]
Song, Zhengxun [1 ,2 ]
Xu, Hongmei [1 ,2 ]
Wang, Zuobin [1 ,2 ,3 ,4 ]
机构
[1] Changchun Univ Sci & Technol, Int Res Ctr Nano Handling & Mfg China, Changchun 130022, Peoples R China
[2] Changchun Univ Sci & Technol, Minist Educ Key Lab Cross Scale Micro & Nano Mfg, Changchun 130022, Peoples R China
[3] Univ Bedfordshire, JR3CN, Luton LU1 3JU, Beds, England
[4] Univ Bedfordshire, IRAC, Luton LU1 3JU, Beds, England
基金
欧盟地平线“2020”; 国家重点研发计划;
关键词
self-assembly; DNA molecule; atomic force microscopy; magnetic field; ATOMIC-FORCE MICROSCOPY; ORIGAMI; EXPOSURE; CELLS; TECHNOLOGY; NANORODS; LEUKEMIA; DEVICES; WORKERS; SURFACE;
D O I
10.1088/1361-6528/ac084f
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
In this work, a rich variety of self-assembled DNA patterns were obtained in the magnetic field. Herein, atomic force microscopy (AFM) was utilized to investigate the effects of the concentration of DNA solution, intensity and direction of magnetic field and modification of mica surface by different cations on the self-assembly of DNA molecules. It was found that owning to the change of the DNA concentration, even under the same magnetic field, the DNA self-assembly results were different. The in situ test results showed that the DNA self-assembly in an magnetic field was more likely to occur in liquid phase than in gas phase. In addition, whether in a horizontal or vertical magnetic field, a single stretched dsDNA was obtained in a certain DNA concentration and magnetic field intensity. Besides, the modification of cations on the mica surface significantly increased the force between the DNA molecules and mica surface, and further changed the self-assembly of DNA molecules under the action of magnetic field.
引用
收藏
页数:10
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